Big bottlenecks in cardiovascular tissue engineering

Ngan F. Huang; Vahid Serpooshan; Viola B. Morris; Nazish Sayed; Gaspard Pardon; Oscar J. Abilez; Karina H. Nakayama; Beth L. Pruitt; Sean M. Wu; Young sup Yoon; Jianyi Zhang; Joseph C. Wu

doi:10.1038/s42003-018-0202-8

Big bottlenecks in cardiovascular tissue engineering

Ngan F. Huang, Vahid Serpooshan, Viola B. Morris, Nazish Sayed, Gaspard Pardon, Oscar J. Abilez, Karina H. Nakayama, Beth L. Pruitt, Sean M. Wu, Young sup Yoon, Jianyi Zhang, Joseph C. Wu

Research output: Contribution to journal › Comment/debate › peer-review

61 Scopus citations

Abstract

Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

Original language	English (US)
Article number	199
Journal	Communications Biology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1038/s42003-018-0202-8
State	Published - Dec 1 2018
Externally published	Yes

ASJC Scopus subject areas

Medicine (miscellaneous)
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1038/s42003-018-0202-8

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title = "Big bottlenecks in cardiovascular tissue engineering",

abstract = "Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.",

author = "Huang, {Ngan F.} and Vahid Serpooshan and Morris, {Viola B.} and Nazish Sayed and Gaspard Pardon and Abilez, {Oscar J.} and Nakayama, {Karina H.} and Pruitt, {Beth L.} and Wu, {Sean M.} and Yoon, {Young sup} and Jianyi Zhang and Wu, {Joseph C.}",

note = "Publisher Copyright: {\textcopyright} 2018, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",

year = "2018",

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day = "1",

doi = "10.1038/s42003-018-0202-8",

language = "English (US)",

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T1 - Big bottlenecks in cardiovascular tissue engineering

AU - Huang, Ngan F.

AU - Serpooshan, Vahid

AU - Morris, Viola B.

AU - Sayed, Nazish

AU - Pardon, Gaspard

AU - Abilez, Oscar J.

AU - Nakayama, Karina H.

AU - Pruitt, Beth L.

AU - Wu, Sean M.

AU - Yoon, Young sup

AU - Zhang, Jianyi

AU - Wu, Joseph C.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

AB - Although tissue engineering using human-induced pluripotent stem cells is a promising approach for treatment of cardiovascular diseases, some limiting factors include the survival, electrical integration, maturity, scalability, and immune response of three-dimensional (3D) engineered tissues. Here we discuss these important roadblocks facing the tissue engineering field and suggest potential approaches to overcome these challenges.

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U2 - 10.1038/s42003-018-0202-8

DO - 10.1038/s42003-018-0202-8

M3 - Comment/debate

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AN - SCOPUS:85070003844

SN - 2399-3642

VL - 1

JO - Communications Biology

JF - Communications Biology

IS - 1

M1 - 199

ER -

Big bottlenecks in cardiovascular tissue engineering

Abstract

ASJC Scopus subject areas

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