TY - JOUR
T1 - Bimodal patterns of human melatonin secretion consistent with a two-oscillator model of regulation
AU - Wehr, Thomas A.
AU - Schwartz, Paul J.
AU - Turner, Erick H.
AU - Feldman-Naim, Susana
AU - Drake, Christopher L.
AU - Rosenthal, Norman E.
PY - 1995/7/14
Y1 - 1995/7/14
N2 - In many animals, changes in duration of nocturnal melatonin secretion chemically mediate effects of seasonal changes in nightlength on behavior and physiology. According to one model, the changes in duration of secretion result from adjustments in the timing of two circadian oscillators, one entrained to dusk, controlling onset, and another entrained to dawn, controlling offset. Consistent with this model, in six women, we found separate and reproducible evening and morning peaks of melatonin secretion that might represent the separate expressions of rhythms of two oscillators.
AB - In many animals, changes in duration of nocturnal melatonin secretion chemically mediate effects of seasonal changes in nightlength on behavior and physiology. According to one model, the changes in duration of secretion result from adjustments in the timing of two circadian oscillators, one entrained to dusk, controlling onset, and another entrained to dawn, controlling offset. Consistent with this model, in six women, we found separate and reproducible evening and morning peaks of melatonin secretion that might represent the separate expressions of rhythms of two oscillators.
KW - Circadian rhythm
KW - Light
KW - Melatonin
KW - Photoperiod
KW - Season
KW - Seasonal affective disorder
UR - http://www.scopus.com/inward/record.url?scp=0029077391&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029077391&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(95)11740-N
DO - 10.1016/0304-3940(95)11740-N
M3 - Article
C2 - 7478188
AN - SCOPUS:0029077391
SN - 0304-3940
VL - 194
SP - 105
EP - 108
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -