TY - JOUR
T1 - Binge eating disorder and medical comorbidities in bariatric surgery candidates
AU - Mitchell, James E.
AU - King, Wendy C.
AU - Pories, Walter
AU - Wolfe, Bruce
AU - Flum, David R.
AU - Spaniolas, Konstatinos
AU - Bessler, Mark
AU - Devlin, Michael
AU - Marcus, Marsha D.
AU - Kalarchian, Melissa
AU - Engel, Scott
AU - Khandelwal, Saurobh
AU - Yanovski, Susan
N1 - Publisher Copyright:
© 2014 Wiley Periodicals, Inc.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Objective To determine whether binge eating disorder (BED) status is associated with medical comorbidities in obese adults scheduled for bariatric surgery. Method The study utilized Longitudinal Assessment of Bariatric Surgery-2 data obtained from six clinical centers around the United States. This is a well-phenotyped cohort of individuals who were evaluated within 30 days before their scheduled surgery using standardized protocols. In the cohort, 350 participants were classified as having BED and 1,875 as not having BED (non-BED). Multivariable logistic regression was used to determine whether BED status was independently related to medical comorbidities. As an exploratory analysis, significance was based on nominal p-values (p<.05). Holm's-adjusted p-values were also reported. Results After adjusting for age, sex, education, and body mass index, BED status was found to be independently associated with four of the 15 comorbidities (i.e., impaired glucose levels (odds ratio [OR]=1.45 (95% confidence interval [CI]: 1.12-1.87)), high triglycerides (OR=1.28 (95% CI: 1.002-1.63)), and urinary incontinence (OR=1.30 (95% CI: 1.02-1.66)), all being more common among the BED sample, and severe walking limitations being less common in the BED sample (OR=0.53 (95% CI: 0.29-0.96)). With further adjustment for psychiatric/emotional health indicators, BED status was independently associated with three comorbidities (impaired glucose levels (OR=1.36 (95% CI: 1.04-1.79)), cardiovascular disease (OR=0.50 (95% CI: 0.30-0.86)), and severe walking limitations (OR=0.38 (95% CI: 0.19-0.77)). However, Holm's-adjusted p-values for all variables were greater than.05. Discussion The results suggest the possibility of a contribution of BED to risk of specific medical comorbidities in severely obese adults.
AB - Objective To determine whether binge eating disorder (BED) status is associated with medical comorbidities in obese adults scheduled for bariatric surgery. Method The study utilized Longitudinal Assessment of Bariatric Surgery-2 data obtained from six clinical centers around the United States. This is a well-phenotyped cohort of individuals who were evaluated within 30 days before their scheduled surgery using standardized protocols. In the cohort, 350 participants were classified as having BED and 1,875 as not having BED (non-BED). Multivariable logistic regression was used to determine whether BED status was independently related to medical comorbidities. As an exploratory analysis, significance was based on nominal p-values (p<.05). Holm's-adjusted p-values were also reported. Results After adjusting for age, sex, education, and body mass index, BED status was found to be independently associated with four of the 15 comorbidities (i.e., impaired glucose levels (odds ratio [OR]=1.45 (95% confidence interval [CI]: 1.12-1.87)), high triglycerides (OR=1.28 (95% CI: 1.002-1.63)), and urinary incontinence (OR=1.30 (95% CI: 1.02-1.66)), all being more common among the BED sample, and severe walking limitations being less common in the BED sample (OR=0.53 (95% CI: 0.29-0.96)). With further adjustment for psychiatric/emotional health indicators, BED status was independently associated with three comorbidities (impaired glucose levels (OR=1.36 (95% CI: 1.04-1.79)), cardiovascular disease (OR=0.50 (95% CI: 0.30-0.86)), and severe walking limitations (OR=0.38 (95% CI: 0.19-0.77)). However, Holm's-adjusted p-values for all variables were greater than.05. Discussion The results suggest the possibility of a contribution of BED to risk of specific medical comorbidities in severely obese adults.
KW - binge eating disorder
KW - medical comorbidities
KW - metabolic syndrome
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U2 - 10.1002/eat.22389
DO - 10.1002/eat.22389
M3 - Article
C2 - 25778499
AN - SCOPUS:84931833051
SN - 0276-3478
VL - 48
SP - 471
EP - 476
JO - International Journal of Eating Disorders
JF - International Journal of Eating Disorders
IS - 5
ER -