@article{a2746fdcf3f44a4fb24224288fbf4604,
title = "Bleomycin-mediated DNA cross-links are dependent on closed-circular molecules with superhelical turns",
abstract = "Non-covalent intermolecular DNA cross-links are created by reaction with the antitumor antibiotic, bleomycin. The cross-links are observed only when the reactant covalently closed circular duplex DNA contains either positive or negative superhelical turns. Multiple sites of cross-linking often extend over 500 base-pairs or more in length.",
author = "Lloyd, {R. S.} and Robberson, {D. L.} and Haidle, {C. W.}",
note = "Funding Information: We are especially grateful to Drs. H.B. Gray, Jr. and Paul Lau for the generous gift of PM2 DNA samples differing in superhelix densities. We also thank Janie Finch and Janet Naquin for help in preparation of the manuscript. This investigation was supported in part, by Grants CA-16527 and CA-13246 awarded by the National Cancer Institute, D.H.E.W. and G-441 from the Robert A. Welch Foundation. R.S.L. was a Postdoctoral Fellow with The Robert A. Welch Foundation.",
year = "1981",
month = feb,
doi = "10.1016/0009-2797(81)90088-0",
language = "English (US)",
volume = "34",
pages = "39--46",
journal = "Chemico-Biological Interactions",
issn = "0009-2797",
publisher = "Elsevier Ireland Ltd",
number = "1",
}