TY - JOUR
T1 - Blood pressure regulation by the angiotensin type 1 receptor in the proximal tubule
AU - Van Haaster, Marloes C.
AU - McDonough, Alicia A.
AU - Gurley, Susan B.
N1 - Publisher Copyright:
Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Purpose of review: The renin-angiotensin system (RAS) plays a critical role in the pathogenesis of hypertension. Homeostatic actions of the RAS, such as increasing blood pressure (BP) and vasoconstriction, are mediated via type 1 (AT 1) receptors for angiotensin II. All components of the RAS are present in the renal proximal tubule, which reabsorbs the bulk of the glomerular filtrate, making this segment of the nephron a location of great interest for solute handling under RAS influence. This review highlights recent studies that illustrate the key role of renal proximal tubule AT 1 receptors in BP regulation. Recent findings: A variety of investigative approaches have demonstrated that angiotensin II signaling via AT 1a receptors, specifically in the renal proximal tubule, is a major regulator of BP and sodium homeostasis. Reduction of proximal tubule AT 1a receptors led to lower BPs, whereas overexpression generally caused increased BPs. Summary: AT 1a receptors in the proximal tubule are critical to the regulation of BP by the kidney and the RAS. The pattern of BP modulation is associated with alterations in sodium transporters. As a key site for sodium homeostasis, the renal proximal tubule could hence be a potential target in the treatment of hypertension.
AB - Purpose of review: The renin-angiotensin system (RAS) plays a critical role in the pathogenesis of hypertension. Homeostatic actions of the RAS, such as increasing blood pressure (BP) and vasoconstriction, are mediated via type 1 (AT 1) receptors for angiotensin II. All components of the RAS are present in the renal proximal tubule, which reabsorbs the bulk of the glomerular filtrate, making this segment of the nephron a location of great interest for solute handling under RAS influence. This review highlights recent studies that illustrate the key role of renal proximal tubule AT 1 receptors in BP regulation. Recent findings: A variety of investigative approaches have demonstrated that angiotensin II signaling via AT 1a receptors, specifically in the renal proximal tubule, is a major regulator of BP and sodium homeostasis. Reduction of proximal tubule AT 1a receptors led to lower BPs, whereas overexpression generally caused increased BPs. Summary: AT 1a receptors in the proximal tubule are critical to the regulation of BP by the kidney and the RAS. The pattern of BP modulation is associated with alterations in sodium transporters. As a key site for sodium homeostasis, the renal proximal tubule could hence be a potential target in the treatment of hypertension.
KW - angiotensin type 1 receptor
KW - hypertension
KW - proximal tubule
KW - renin-angiotensin system
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U2 - 10.1097/MNH.0000000000000373
DO - 10.1097/MNH.0000000000000373
M3 - Review article
C2 - 29045337
AN - SCOPUS:85036659349
SN - 1062-4821
VL - 27
SP - 1
EP - 7
JO - Current opinion in nephrology and hypertension
JF - Current opinion in nephrology and hypertension
IS - 1
ER -