Brain-stem auditory evoked responses to hypercarbia in preterm infants

Helena E. Friss; Dorothy Wavrek; William H. Martin; Marla R. Wolfson

doi:10.1016/0013-4694(94)90049-3

Brain-stem auditory evoked responses to hypercarbia in preterm infants

Helena E. Friss
, Dorothy Wavrek
, William H. Martin
, Marla R. Wolfson

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

To determine the effect of acute hypercarbia on brain-stem function in preterm neonates, we compared brain-stem auditory evoked responses (BAERs) during 8% CO₂ breathing to those elicited during room air breathing in 12 healthy preterm infants during the first week of life. End-tidal CO₂ (ETpCO₂), respiratory rate and depth were monitored throughout the protocol. Absolute wave latencies and interpeak intervals of the BAERs were ana;yzed from duplicate trials. During 8% CO₂ breathing, ETpCO₂, respiratory rate depth of respiration increased significantly (p < 0.05). The absolute latency of wave V was prolonged (P < 0.025). Values of absolute peak latencies I and III were unaffected by the hypercarbic state. These data demonstrate that elevations in pCO₂ which elicit ventilatory responses also effect the BAER. The specific effects on ventilatory pattern, peak V latency and interpeak interval III-V indicate brain-stem responsiveness and alterations in the more central components of the auditory pathway. These findings raise important considerations regarding the influence of hypercarbia on brain-stem function preterm infants and the clinical management of such infants with abnormalities of gas exchange.

Original language	English (US)
Pages (from-to)	331-336
Number of pages	6
Journal	Electroencephalography and Clinical Neurophysiology
Volume	90
Issue number	5
DOIs	https://doi.org/10.1016/0013-4694(94)90049-3
State	Published - May 1994
Externally published	Yes

Funding

Supported in part by the ** National Institutes of Health Grant, R29HD26341-01, and * The Garfield Foundation, Princeton, NJ. Presented in part at the meetings of the Society for Pediatric Research, 1991, New Orleans, LA.

Funders	Funder number
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health	R29HD26341-01
Garfield Foundation
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health	R29HD026341

Keywords

Brain-stem auditory evoked response (BAER)
Hypercarbia
Preterm infant

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

Access to Document

10.1016/0013-4694(94)90049-3

Cite this

@article{a5dfd874b46e4f89b42f750a45bf117d,

title = "Brain-stem auditory evoked responses to hypercarbia in preterm infants",

abstract = "To determine the effect of acute hypercarbia on brain-stem function in preterm neonates, we compared brain-stem auditory evoked responses (BAERs) during 8\% CO2 breathing to those elicited during room air breathing in 12 healthy preterm infants during the first week of life. End-tidal CO2 (ETpCO2), respiratory rate and depth were monitored throughout the protocol. Absolute wave latencies and interpeak intervals of the BAERs were ana;yzed from duplicate trials. During 8\% CO2 breathing, ETpCO2, respiratory rate depth of respiration increased significantly (p < 0.05). The absolute latency of wave V was prolonged (P < 0.025). Values of absolute peak latencies I and III were unaffected by the hypercarbic state. These data demonstrate that elevations in pCO2 which elicit ventilatory responses also effect the BAER. The specific effects on ventilatory pattern, peak V latency and interpeak interval III-V indicate brain-stem responsiveness and alterations in the more central components of the auditory pathway. These findings raise important considerations regarding the influence of hypercarbia on brain-stem function preterm infants and the clinical management of such infants with abnormalities of gas exchange.",

keywords = "Brain-stem auditory evoked response (BAER), Hypercarbia, Preterm infant",

author = "Friss, \{Helena E.\} and Dorothy Wavrek and Martin, \{William H.\} and Wolfson, \{Marla R.\}",

note = "Funding Information: Supported in part by the ** National Institutes of Health Grant, R29HD26341-01, and * The Garfield Foundation, Princeton, NJ. Presented in part at the meetings of the Society for Pediatric Research, 1991, New Orleans, LA.",

year = "1994",

month = may,

doi = "10.1016/0013-4694(94)90049-3",

language = "English (US)",

volume = "90",

pages = "331--336",

journal = "Electroencephalography and Clinical Neurophysiology",

issn = "0013-4694",

publisher = "Elsevier Ireland Ltd",

number = "5",

}

TY - JOUR

T1 - Brain-stem auditory evoked responses to hypercarbia in preterm infants

AU - Friss, Helena E.

AU - Wavrek, Dorothy

AU - Martin, William H.

AU - Wolfson, Marla R.

N1 - Funding Information: Supported in part by the ** National Institutes of Health Grant, R29HD26341-01, and * The Garfield Foundation, Princeton, NJ. Presented in part at the meetings of the Society for Pediatric Research, 1991, New Orleans, LA.

PY - 1994/5

Y1 - 1994/5

N2 - To determine the effect of acute hypercarbia on brain-stem function in preterm neonates, we compared brain-stem auditory evoked responses (BAERs) during 8% CO2 breathing to those elicited during room air breathing in 12 healthy preterm infants during the first week of life. End-tidal CO2 (ETpCO2), respiratory rate and depth were monitored throughout the protocol. Absolute wave latencies and interpeak intervals of the BAERs were ana;yzed from duplicate trials. During 8% CO2 breathing, ETpCO2, respiratory rate depth of respiration increased significantly (p < 0.05). The absolute latency of wave V was prolonged (P < 0.025). Values of absolute peak latencies I and III were unaffected by the hypercarbic state. These data demonstrate that elevations in pCO2 which elicit ventilatory responses also effect the BAER. The specific effects on ventilatory pattern, peak V latency and interpeak interval III-V indicate brain-stem responsiveness and alterations in the more central components of the auditory pathway. These findings raise important considerations regarding the influence of hypercarbia on brain-stem function preterm infants and the clinical management of such infants with abnormalities of gas exchange.

AB - To determine the effect of acute hypercarbia on brain-stem function in preterm neonates, we compared brain-stem auditory evoked responses (BAERs) during 8% CO2 breathing to those elicited during room air breathing in 12 healthy preterm infants during the first week of life. End-tidal CO2 (ETpCO2), respiratory rate and depth were monitored throughout the protocol. Absolute wave latencies and interpeak intervals of the BAERs were ana;yzed from duplicate trials. During 8% CO2 breathing, ETpCO2, respiratory rate depth of respiration increased significantly (p < 0.05). The absolute latency of wave V was prolonged (P < 0.025). Values of absolute peak latencies I and III were unaffected by the hypercarbic state. These data demonstrate that elevations in pCO2 which elicit ventilatory responses also effect the BAER. The specific effects on ventilatory pattern, peak V latency and interpeak interval III-V indicate brain-stem responsiveness and alterations in the more central components of the auditory pathway. These findings raise important considerations regarding the influence of hypercarbia on brain-stem function preterm infants and the clinical management of such infants with abnormalities of gas exchange.

KW - Brain-stem auditory evoked response (BAER)

KW - Hypercarbia

KW - Preterm infant

UR - https://www.scopus.com/pages/publications/0028292384

UR - https://www.scopus.com/pages/publications/0028292384#tab=citedBy

U2 - 10.1016/0013-4694(94)90049-3

DO - 10.1016/0013-4694(94)90049-3

M3 - Article

C2 - 7514980

AN - SCOPUS:0028292384

SN - 0013-4694

VL - 90

SP - 331

EP - 336

JO - Electroencephalography and Clinical Neurophysiology

JF - Electroencephalography and Clinical Neurophysiology

IS - 5

ER -

Brain-stem auditory evoked responses to hypercarbia in preterm infants

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this