TY - JOUR
T1 - Bromocriptine holiday
T2 - Effects on dopamine receptors and turning behavior in rats
AU - Kenny, Anne M.
AU - Schneider, Michael B.
AU - Baden, Daniel R.
AU - Pfeiffer, Ronald F.
AU - Murrin, L. Charles
PY - 1986/3
Y1 - 1986/3
N2 - In experimental Parkinson’s disease, we studied the effects of chronic administration (30 days), withdrawal, and reinstitution of bromocriptine. Dopamine (DA) receptor supersensitivity was produced by 6-hydroxydopamine and reversed by chronic bromocriptine administration. Drug holiday reestablished sensitivity of DA receptors, but reinstitution of bromocriptine again downregulated receptors. The effects of a drug holiday on DA receptors are shortlived, and long-term clinical improvement cannot be expected. Apomorphineinduced contralateral turning produced by the lesion was unaffected by any drug regimen.
AB - In experimental Parkinson’s disease, we studied the effects of chronic administration (30 days), withdrawal, and reinstitution of bromocriptine. Dopamine (DA) receptor supersensitivity was produced by 6-hydroxydopamine and reversed by chronic bromocriptine administration. Drug holiday reestablished sensitivity of DA receptors, but reinstitution of bromocriptine again downregulated receptors. The effects of a drug holiday on DA receptors are shortlived, and long-term clinical improvement cannot be expected. Apomorphineinduced contralateral turning produced by the lesion was unaffected by any drug regimen.
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U2 - 10.1212/wnl.36.3.400
DO - 10.1212/wnl.36.3.400
M3 - Article
C2 - 3081831
AN - SCOPUS:0022644145
SN - 0028-3878
VL - 36
SP - 400
EP - 404
JO - Neurology
JF - Neurology
IS - 3
ER -