Bromocriptine holiday: Effects on dopamine receptors and turning behavior in rats

Anne M. Kenny, Michael B. Schneider, Daniel R. Baden, Ronald F. Pfeiffer, L. Charles Murrin

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


In experimental Parkinson’s disease, we studied the effects of chronic administration (30 days), withdrawal, and reinstitution of bromocriptine. Dopamine (DA) receptor supersensitivity was produced by 6-hydroxydopamine and reversed by chronic bromocriptine administration. Drug holiday reestablished sensitivity of DA receptors, but reinstitution of bromocriptine again downregulated receptors. The effects of a drug holiday on DA receptors are shortlived, and long-term clinical improvement cannot be expected. Apomorphineinduced contralateral turning produced by the lesion was unaffected by any drug regimen.

Original languageEnglish (US)
Pages (from-to)400-404
Number of pages5
Issue number3
StatePublished - Mar 1986
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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