@article{74f0771568414b4e952d2c3f52868235,
title = "Bronchodilator Responsiveness and Reported Respiratory Symptoms in an Adult Population",
abstract = "Background: The relationship between patient-reported symptoms and objective measures of lung function is poorly understood. Aim: To determine the association between responsiveness to bronchodilator and respiratory symptoms in random population samples. Methods: 4669 people aged 40 years and older from 8 sites in Canada completed interviewer-administered respiratory questionnaires and performed spirometry before and after administration of 200 ug of inhaled salbutamol. The effect of anthropometric variables, smoking exposure and doctor-diagnosed asthma (DDA) on bronchodilator responsiveness in forced expiratory volume in 1 second (FEV1) and in forced vital capacity (FVC) were evaluated. Multiple logistic regression was used to test for association between quintiles of increasing changes in FEV1 and in FVC after bronchodilator and several respiratory symptoms. Results: Determinants of bronchodilator change in FEV1 and FVC included age, DDA, smoking, respiratory drug use and female gender [p<0.005 to p<0.0001]. In subjects without doctor-diagnosed asthma or COPD, bronchodilator response in FEV1 was associated with wheezing [p for trend<0.0001], while bronchodilator response for FVC was associated with breathlessness. [p for trend <0.0001]. Conclusions: Bronchodilator responsiveness in FEV1 or FVC are associated with different respiratory symptoms in the community. Both flow and volume bronchodilator responses are useful parameters which together can be predictive of both wheezing and breathlessness in the general population.",
author = "Tan, {Wan C.} and Jean Bourbeau and Paul Hernandez and Chapman, {Kenneth R.} and Robert Cowie and FitzGerald, {J. Mark} and Shawn Aaron and Marciniuk, {Darcy D.} and Francois Maltais and Buist, {A. Sonia} and O'Donnell, {Denis E.} and Sin, {Don D.}",
note = "Funding Information: The authors have read the journal{\textquoteright}s policy and have the following conflicts: Wan C. Tan has received funding for the Canadian Obstructive Lung Disease epidemiological study Operations from unrestricted educational grants from GlaxoSmithKline, Pfizer, Boehringer Ingelheim, AstraZeneca. Dr. Kenneth Chapman holds the GSK-CIHR Research Chair in Respiratory Health Care Delivery at the University Health Network, Toronto, Canada. In the past five years, Dr. Marciniuk received funding support to attend a symposium from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Nycomed, and Pfizer; for speaking from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Nycomed, and Pfizer; for consulting from AstraZeneca, Canadian Agency for Drugs and Technology in Health, GlaxoSmithKline, Health Canada, Health Quality Council, Novartis, Nycomed, Pfizer, Public Health Agency of Canada, Saskatchewan Medical Association and the Saskatoon Health Region; for research (directed to the University of Saskatchewan) from AstraZeneca, Boehringer Ingelheim, Canadian Agency for Drugs and Technology in Health, Canadian Institute of Health Research, Dalhousie University, Forest Research, GlaxoSmithKline, Lung Association of Saskatchewan, McGill University, Nycomed, Saskatchewan Health Research Foundation, Saskatchewan Ministry of Health, Schering, Pfizer, and the University of Alberta; and for organizing education from the American College of Chest Physicians, Boehringer Ingelheim, Canadian Thoracic Society, Merck, Nycomed, and the University of Saskatchewan. Dr. Marciniuk is an employee of the University of Saskatchewan. A.S. Buist has received unrestricted educational grants from GlaxoSmithKline (GSK), AstraZeneca (AZ), Novartis, Chiesi, Merck, Boehringer Ingelheim to the BOLD operation Center at Kaiser Center for health Research, Portland, Oregon, and served on advisory boards for GSK, Merck, Novartis and AZ. Denis O{\textquoteright}Donnell has served on advisory boards for Boehringer Ingelheim, Pfizer, GSK, Novartis, and Nycomed; has received lecture fees from Boehringer Ingelheim, Astra Zeneca, Pfizer, and GSK; and has received industry-sponsored grants from Boehringer Ingelheim, GSK, and Merck Frosst Canada and from Novartis and Pfizer. Paul Hernandez has participated during the past five years on medical advisory boards for Actelion, AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Merck, Novartis, Nycomed, and Pfizer; has conducted clinical research funded by &SetFont Typeface={"}43{"};Actelion, AstraZeneca, Boehringer Ingelheim, CSL Behring, Eli Lilly, GlaxoSmithKline, Novartis, Nycomed, and Pfizer; and received support to travel to ERS Congress from AstraZeneca. Jean Bourbeau, Francois Maltais, Don D. Sin, Robert Cowie, J. Mark FitzGerald, Shawn Aaron have no conflict of interest to declare. This does not alter the authors{\textquoteright} adherence to all the PLOS ONE policies on sharing data and materials. ",
year = "2013",
month = mar,
day = "15",
doi = "10.1371/journal.pone.0058932",
language = "English (US)",
volume = "8",
journal = "PloS one",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",
}