TY - JOUR
T1 - Butyrate
T2 - More Than a Short Chain Fatty Acid
AU - Mohamed Elfadil, Osman
AU - Mundi, Manpreet S.
AU - Abdelmagid, Marwa G.
AU - Patel, Ankitaben
AU - Patel, Nishant
AU - Martindale, Robert
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023/6
Y1 - 2023/6
N2 - Purpose of Review: The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus of microbiome understanding. This brief review aims to describe butyrate’s relation to certain biological concepts and their clinical application. Recent Findings: Butyrate has reportedly been described as a potent pro-resolution molecule that has a significant role in maintaining gut immunity, supporting gut barrier function, regulation of histone deacetylase (HDAC), and numerous systemic roles. Further research is needed to explore potential benefits of adding SCFAs for patients receiving total parenteral nutrition. Summary: Butyrate plays several biological roles in intestinal epithelium anti-inflammatory pathways with clear benefits in numerous acute and chronic disease states and overall human health helping to maintain homeostasis.
AB - Purpose of Review: The mechanistic understanding of the importance and the potential benefits of the gut microbiome has exploded in potential roles in human health and disease. Short chain fatty acids (SCFAs), including butyrate, are one of the key metabolic end products that has been a major focus of microbiome understanding. This brief review aims to describe butyrate’s relation to certain biological concepts and their clinical application. Recent Findings: Butyrate has reportedly been described as a potent pro-resolution molecule that has a significant role in maintaining gut immunity, supporting gut barrier function, regulation of histone deacetylase (HDAC), and numerous systemic roles. Further research is needed to explore potential benefits of adding SCFAs for patients receiving total parenteral nutrition. Summary: Butyrate plays several biological roles in intestinal epithelium anti-inflammatory pathways with clear benefits in numerous acute and chronic disease states and overall human health helping to maintain homeostasis.
KW - Butyrate
KW - Gut microbiome
KW - Parenteral nutrition
KW - Short chain fatty acids
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U2 - 10.1007/s13668-023-00461-4
DO - 10.1007/s13668-023-00461-4
M3 - Review article
C2 - 36763294
AN - SCOPUS:85147767761
SN - 2161-3311
VL - 12
SP - 255
EP - 262
JO - Current Nutrition Reports
JF - Current Nutrition Reports
IS - 2
ER -