TY - JOUR
T1 - Caenorhabditis elegans as a host for the study of host-pathogen interactions
AU - Aballay, Alejandro
AU - Ausubel, Frederick M.
PY - 2002
Y1 - 2002
N2 - Recently, pathogenicity models that involve the killing of the genetically tractable nematode Caenorhabditis elegans by human pathogens have been developed. From the perspective of the pathogen, the advantage of these models is that thousands of mutagenized bacterial clones can be individually screened for avirulent mutants on separate petri plates seeded with C. elegans. The advantages of using C. elegans to study host responses to pathogen attack are the extensive genetic and genomic resources available and the relative ease of identifying C. elegans mutants that exhibit altered susceptibility to pathogen attack. The use of Caenorhabditis elegans as the host for a variety of human pathogens is discussed.
AB - Recently, pathogenicity models that involve the killing of the genetically tractable nematode Caenorhabditis elegans by human pathogens have been developed. From the perspective of the pathogen, the advantage of these models is that thousands of mutagenized bacterial clones can be individually screened for avirulent mutants on separate petri plates seeded with C. elegans. The advantages of using C. elegans to study host responses to pathogen attack are the extensive genetic and genomic resources available and the relative ease of identifying C. elegans mutants that exhibit altered susceptibility to pathogen attack. The use of Caenorhabditis elegans as the host for a variety of human pathogens is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0036164933&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036164933&partnerID=8YFLogxK
U2 - 10.1016/S1369-5274(02)00293-X
DO - 10.1016/S1369-5274(02)00293-X
M3 - Review article
C2 - 11834377
AN - SCOPUS:0036164933
SN - 1369-5274
VL - 5
SP - 97
EP - 101
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
IS - 1
ER -