Caenorhabditis elegans as a host for the study of host-pathogen interactions

Alejandro Aballay, Frederick M. Ausubel

Research output: Contribution to journalReview articlepeer-review

146 Scopus citations


Recently, pathogenicity models that involve the killing of the genetically tractable nematode Caenorhabditis elegans by human pathogens have been developed. From the perspective of the pathogen, the advantage of these models is that thousands of mutagenized bacterial clones can be individually screened for avirulent mutants on separate petri plates seeded with C. elegans. The advantages of using C. elegans to study host responses to pathogen attack are the extensive genetic and genomic resources available and the relative ease of identifying C. elegans mutants that exhibit altered susceptibility to pathogen attack. The use of Caenorhabditis elegans as the host for a variety of human pathogens is discussed.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalCurrent Opinion in Microbiology
Issue number1
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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