Calibration of rotational acceleration for the rotarod test of rodent motor coordination

Martin Bohlen; Andy Cameron; Pamela Metten; John C. Crabbe; Douglas Wahlsten

doi:10.1016/j.jneumeth.2008.11.001

Calibration of rotational acceleration for the rotarod test of rodent motor coordination

Martin Bohlen, Andy Cameron, Pamela Metten, John C. Crabbe, Douglas Wahlsten

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The latency of mice and rats to fall from the accelerating rotarod can differ markedly between laboratories using the same brand of rod as well as between studies using different kinds of rods. These discrepancies can arise from different rod diameters, surface textures, test protocols, or laboratory environmental factors beyond the test itself, but it is also possible that the actual acceleration rates of the different rods do not correspond to the nominal rates set on the devices. This paper describes a simple method to measure acceleration rate of the rotarod and to set the rate to a desired value for any brand of rod.

Original language	English (US)
Pages (from-to)	10-14
Number of pages	5
Journal	Journal of Neuroscience Methods
Volume	178
Issue number	1
DOIs	https://doi.org/10.1016/j.jneumeth.2008.11.001
State	Published - Mar 30 2009
Externally published	Yes

Keywords

Behavioral test
Motor coordination
Mouse
Rat
Rotarod
Task parameters
Test standardization

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.jneumeth.2008.11.001

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title = "Calibration of rotational acceleration for the rotarod test of rodent motor coordination",

abstract = "The latency of mice and rats to fall from the accelerating rotarod can differ markedly between laboratories using the same brand of rod as well as between studies using different kinds of rods. These discrepancies can arise from different rod diameters, surface textures, test protocols, or laboratory environmental factors beyond the test itself, but it is also possible that the actual acceleration rates of the different rods do not correspond to the nominal rates set on the devices. This paper describes a simple method to measure acceleration rate of the rotarod and to set the rate to a desired value for any brand of rod.",

keywords = "Behavioral test, Motor coordination, Mouse, Rat, Rotarod, Task parameters, Test standardization",

author = "Martin Bohlen and Andy Cameron and Pamela Metten and Crabbe, {John C.} and Douglas Wahlsten",

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AU - Bohlen, Martin

AU - Cameron, Andy

AU - Metten, Pamela

AU - Crabbe, John C.

AU - Wahlsten, Douglas

N1 - Funding Information: This research was supported by NIH/NIAAA grant AA012714 to D.W.

PY - 2009/3/30

Y1 - 2009/3/30

N2 - The latency of mice and rats to fall from the accelerating rotarod can differ markedly between laboratories using the same brand of rod as well as between studies using different kinds of rods. These discrepancies can arise from different rod diameters, surface textures, test protocols, or laboratory environmental factors beyond the test itself, but it is also possible that the actual acceleration rates of the different rods do not correspond to the nominal rates set on the devices. This paper describes a simple method to measure acceleration rate of the rotarod and to set the rate to a desired value for any brand of rod.

AB - The latency of mice and rats to fall from the accelerating rotarod can differ markedly between laboratories using the same brand of rod as well as between studies using different kinds of rods. These discrepancies can arise from different rod diameters, surface textures, test protocols, or laboratory environmental factors beyond the test itself, but it is also possible that the actual acceleration rates of the different rods do not correspond to the nominal rates set on the devices. This paper describes a simple method to measure acceleration rate of the rotarod and to set the rate to a desired value for any brand of rod.

KW - Behavioral test

KW - Motor coordination

KW - Mouse

KW - Rat

KW - Rotarod

KW - Task parameters

KW - Test standardization

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Calibration of rotational acceleration for the rotarod test of rodent motor coordination

Abstract

Keywords

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