@article{44a1118069cb417da4c80e36ff8d2872,
title = "Cardiovascular Manifestations From Therapeutic Radiation: A Multidisciplinary Expert Consensus Statement From the International Cardio-Oncology Society",
abstract = "Radiation therapy is a cornerstone of cancer therapy, with >50% of patients undergoing therapeutic radiation. As a result of widespread use and improved survival, there is increasing focus on the potential long-term effects of ionizing radiation, especially cardiovascular toxicity. Radiation therapy can lead to atherosclerosis of the vasculature as well as valvular, myocardial, and pericardial dysfunction. We present a consensus statement from the International Cardio-Oncology Society based on general principles of radiotherapy delivery and cardiovascular risk assessment and risk mitigation in this population. Anatomical-based recommendations for cardiovascular management and follow-up are provided, and a priority is given to the early detection of atherosclerotic vascular disease on imaging to help guide preventive therapy. Unique management considerations in radiation-induced cardiovascular disease are also discussed. Recommendations are based on the most current literature and represent a unanimous consensus by the multidisciplinary expert panel.",
keywords = "cancer, cardiovascular disease, imaging, prevention, radiation therapy, screening",
author = "Mitchell, {Joshua D.} and Cehic, {Daniel A.} and Marita Morgia and Carmen Bergom and Joanne Toohey and Guerrero, {Patricia A.} and Maros Ferencik and Robin Kikuchi and Carver, {Joseph R.} and Zaha, {Vlad G.} and Alvarez-Cardona, {Jose A.} and Sebastian Szmit and Daniele, {Andr{\'e}s J.} and Juan Lopez-Mattei and Lili Zhang and J{\"o}rg Herrmann and Anju Nohria and Lenihan, {Daniel J.} and Dent, {Susan F.}",
note = "Funding Information: Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR002345 as well as by the National Institutes of Health grant R01 HL147884. Dr Mitchell has received research funding from Pfizer, Longer Life Foundation, and Children{\textquoteright}s Discovery Institute; and is a consultant for Pfizer (modest). Dr Bergom has received research support from the Susan G. Komen Foundation and Innovation Pathways. Dr Ferencik has received research support from the National Institutes of Health and the American Heart Association; and is a consultant for Biograph, Inc (unrelated to current work). Dr Szmit has received personal fees from Amgen, Angelini, AstraZeneca, Bayer, Berlin-Chemie, Bristol Myers Squibb, Clinigen, Janssen-Cilag, Pfizer, Polpharma, Roche, and TEVA. Dr Zaha has received support from the Cancer Prevention Research Institute of Texas (RP180404). Dr Herrmann was supported by the National Cancer Institute of the National Institutes of Health (CA233610), the Miami Heart Foundation, and the Mayo Clinic. Dr Nohria has received research funding from Amgen, Inc; and is a consultant for Takeda Oncology and AstraZeneca. Dr Lenihan has received research funding from Myocardial Solutions; and is a consultant for Lilly, Prothena, AstraZeneca, Roche, Clementia, and Eidos (all consultancy renumeration is modest). Dr Dent has received research funding from Novartis; and is a consultant for Novartis and Eli Lilly. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
month = sep,
doi = "10.1016/j.jaccao.2021.06.003",
language = "English (US)",
volume = "3",
pages = "360--380",
journal = "JACC: CardioOncology",
issn = "2666-0873",
publisher = "Elsevier Inc.",
number = "3",
}