@article{b4b83603000c4a529a5d519169b2084a,
title = "Cas Adaptor Proteins Coordinate Sensory Axon Fasciculation",
abstract = "Development of complex neural circuits like the peripheral somatosensory system requires intricate mechanisms to ensure axons make proper connections. While much is known about ligand-receptor pairs required for dorsal root ganglion (DRG) axon guidance, very little is known about the cytoplasmic effectors that mediate cellular responses triggered by these guidance cues. Here we show that members of the Cas family of cytoplasmic signaling adaptors are highly phosphorylated in central projections of the DRG as they enter the spinal cord. Furthermore, we provide genetic evidence that Cas proteins regulate fasciculation of DRG sensory projections. These data establish an evolutionarily conserved requirement for Cas adaptor proteins during peripheral nervous system axon pathfinding. They also provide insight into the interplay between axonal fasciculation and adhesion to the substrate.",
author = "Vahedi-Hunter, {Tyler A.} and Estep, {Jason A.} and Rosette, {Kylee A.} and Rutlin, {Michael L.} and Wright, {Kevin M.} and Riccomagno, {Martin M.}",
note = "Funding Information: We would like to thank Drs Sachiko Seo and Mineo Kurokawa, and Dr. Konstantina Alexandropoulos for sharing the CasL-/- and Sin-/- mouse lines, respectively. The p130Cas EGFP-Bac line was generated by the GENSAT consortium. We also thank Drs Garret Anderson and Randal Hand for helpful comments on the manuscript. This study was supported by Initial Complementary Funds from the University of California, Riverside, to M.M.R, and R01-NS091027 to K.M.W. Author Contributions Funding Information: We would like to thank Drs Sachiko Seo and Mineo Kurokawa, and Dr. Konstantina Alexandropoulos for sharing the CasL−/− and Sin−/− mouse lines, respectively. The p130Cas EGFP-Bac line was generated by the GENSAT consortium. We also thank Drs Garret Anderson and Randal Hand for helpful comments on the manuscript. This study was supported by Initial Complementary Funds from the University of California, Riverside, to M.M.R, and R01-NS091027 to K.M.W. Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-018-24261-x",
language = "English (US)",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}