TY - JOUR
T1 - Catecholaminergic fiber sprouting in granuloprival coeruleo-cerebellar cultures
AU - Seil, Fredrick J.
AU - Tiekotter, Kenneth L.
AU - Woodward, William R.
N1 - Funding Information:
This study was supported by the Veterans Administration and the Medical Research Foundation of Oregon. Technical assistance was provided bv Jay CaUaway, Cynthia Crake. Petm Gillespie, Paul Kingsley, Dawn Merrick, Gregg Phares and Coral Mirth Walker.
PY - 1985/8
Y1 - 1985/8
N2 - Neonatal mouse coeruleo-cerebellar explants exposed to cytosine arabinoside to destroy granule cell precursors demonstrated sprouting of catecholaminergic fibers after 15 days in vitro. Levels of dopamine in granuloprival coeruleo-cerebellar cultures were more than twice those of control cultures. As granuloprival cerebellar cultures also demonstrate Purkinje cell axon collateral sprouting, the granuloprival coeruleo-cerebellar system, in which there is sprouting of two different neuronal groups, may provide a model to investigate the nature and specificity of the signal or signals that induce axonal sprouting.
AB - Neonatal mouse coeruleo-cerebellar explants exposed to cytosine arabinoside to destroy granule cell precursors demonstrated sprouting of catecholaminergic fibers after 15 days in vitro. Levels of dopamine in granuloprival coeruleo-cerebellar cultures were more than twice those of control cultures. As granuloprival cerebellar cultures also demonstrate Purkinje cell axon collateral sprouting, the granuloprival coeruleo-cerebellar system, in which there is sprouting of two different neuronal groups, may provide a model to investigate the nature and specificity of the signal or signals that induce axonal sprouting.
KW - axonal sprouting
KW - catecholamine
KW - catecholaminergic fiber sprouting
KW - coeruleo-cerebellar explant
KW - granuloprival cerebellar culture
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U2 - 10.1016/0165-3806(85)90213-5
DO - 10.1016/0165-3806(85)90213-5
M3 - Article
C2 - 4041907
AN - SCOPUS:0021924261
SN - 0165-3806
VL - 21
SP - 251
EP - 255
JO - Developmental Brain Research
JF - Developmental Brain Research
IS - 2
ER -