Caudal regression versus sirenomelia: Sonographic clues

D. Twickler, N. Budorick, D. Pretorius, M. Grafe, G. Currarino

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Seven cases with the pathologic/autopsy diagnosis of caudal regression or sirenomelia in which antenatal sonography had been performed were reviewed. The three patients with caudal regression had similar findings on antenatal sonogram, including normal or increased amniotic fluid, mild dilation or normal urinary systems, nonfused extremities, and sacral agenesis. In the four patients with sirenomelia, common sonographic findings included marked oligohydramnios, suspected renal agenesis, and sacral agenesis. A history of maternal diabetes was elicited in all patients with caudal regression and in none of the patients with sirenomelia. Findings confirm recent articles in pediatric pathology suggesting that caudal regression is a separate entity, distinct from sirenomelia.

Original languageEnglish (US)
Pages (from-to)323-330
Number of pages8
JournalJournal of Ultrasound in Medicine
Issue number6
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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