Cell Dissemination in Pancreatic Cancer

Jungsun Kim

doi:10.3390/cells11223683

Cell Dissemination in Pancreatic Cancer

Jungsun Kim

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Pancreatic cancer is a disease notorious for its high frequency of recurrence and low survival rate. Surgery is the most effective treatment for localized pancreatic cancer, but most cancer recurs after surgery, and patients die within ten years of diagnosis. The question persists: what makes pancreatic cancer recur and metastasize with such a high frequency? Herein, we review evidence that subclinical dormant pancreatic cancer cells disseminate before developing metastatic or recurring cancer. We then discuss several routes by which pancreatic cancer migrates and the mechanisms by which pancreatic cancer cells adapt. Lastly, we discuss unanswered questions in pancreatic cancer cell migration and our perspectives.

Original language	English (US)
Article number	3683
Journal	Cells
Volume	11
Issue number	22
DOIs	https://doi.org/10.3390/cells11223683
State	Published - Nov 2022

Keywords

adherens junctions
cell dissemination
collective cell migration
epithelial–mesenchymal transition (EMT)

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.3390/cells11223683

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title = "Cell Dissemination in Pancreatic Cancer",

abstract = "Pancreatic cancer is a disease notorious for its high frequency of recurrence and low survival rate. Surgery is the most effective treatment for localized pancreatic cancer, but most cancer recurs after surgery, and patients die within ten years of diagnosis. The question persists: what makes pancreatic cancer recur and metastasize with such a high frequency? Herein, we review evidence that subclinical dormant pancreatic cancer cells disseminate before developing metastatic or recurring cancer. We then discuss several routes by which pancreatic cancer migrates and the mechanisms by which pancreatic cancer cells adapt. Lastly, we discuss unanswered questions in pancreatic cancer cell migration and our perspectives.",

keywords = "adherens junctions, cell dissemination, collective cell migration, epithelial–mesenchymal transition (EMT)",

author = "Jungsun Kim",

note = "Publisher Copyright: {\textcopyright} 2022 by the author.",

year = "2022",

month = nov,

doi = "10.3390/cells11223683",

language = "English (US)",

volume = "11",

journal = "Cells",

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T1 - Cell Dissemination in Pancreatic Cancer

AU - Kim, Jungsun

PY - 2022/11

Y1 - 2022/11

N2 - Pancreatic cancer is a disease notorious for its high frequency of recurrence and low survival rate. Surgery is the most effective treatment for localized pancreatic cancer, but most cancer recurs after surgery, and patients die within ten years of diagnosis. The question persists: what makes pancreatic cancer recur and metastasize with such a high frequency? Herein, we review evidence that subclinical dormant pancreatic cancer cells disseminate before developing metastatic or recurring cancer. We then discuss several routes by which pancreatic cancer migrates and the mechanisms by which pancreatic cancer cells adapt. Lastly, we discuss unanswered questions in pancreatic cancer cell migration and our perspectives.

AB - Pancreatic cancer is a disease notorious for its high frequency of recurrence and low survival rate. Surgery is the most effective treatment for localized pancreatic cancer, but most cancer recurs after surgery, and patients die within ten years of diagnosis. The question persists: what makes pancreatic cancer recur and metastasize with such a high frequency? Herein, we review evidence that subclinical dormant pancreatic cancer cells disseminate before developing metastatic or recurring cancer. We then discuss several routes by which pancreatic cancer migrates and the mechanisms by which pancreatic cancer cells adapt. Lastly, we discuss unanswered questions in pancreatic cancer cell migration and our perspectives.

KW - adherens junctions

KW - cell dissemination

KW - collective cell migration

KW - epithelial–mesenchymal transition (EMT)

UR - http://www.scopus.com/inward/record.url?scp=85142436959&partnerID=8YFLogxK

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U2 - 10.3390/cells11223683

DO - 10.3390/cells11223683

M3 - Review article

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VL - 11

JO - Cells

JF - Cells

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M1 - 3683

ER -

Cell Dissemination in Pancreatic Cancer

Abstract

Keywords

ASJC Scopus subject areas

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