Cellular uptake of PNA-terpyridine conjugates and its enhancement by Zn2+ ions

Andreas Füssl; Andreas Schleifenbaum; Mareike Göritz; Andrew Riddell; Carsten Schultz; Roland Krämer

doi:10.1021/ja0571139

Cellular uptake of PNA-terpyridine conjugates and its enhancement by Zn²⁺ ions

Andreas Füssl, Andreas Schleifenbaum, Mareike Göritz, Andrew Riddell, Carsten Schultz, Roland Krämer

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Conjugation of usually impermeable peptide nucleic acids (PNA) to the chelator 2,2′:6′,2″-terpyridine strongly promotes cellular and nuclear uptake by cultured HeLa cells. Cellular accumulation is further enhanced in the presence of extracellular Zn²⁺.

Original language	English (US)
Pages (from-to)	5986-5987
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	18
DOIs	https://doi.org/10.1021/ja0571139
State	Published - May 10 2006
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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title = "Cellular uptake of PNA-terpyridine conjugates and its enhancement by Zn2+ ions",

abstract = "Conjugation of usually impermeable peptide nucleic acids (PNA) to the chelator 2,2′:6′,2″-terpyridine strongly promotes cellular and nuclear uptake by cultured HeLa cells. Cellular accumulation is further enhanced in the presence of extracellular Zn2+.",

author = "Andreas F{\"u}ssl and Andreas Schleifenbaum and Mareike G{\"o}ritz and Andrew Riddell and Carsten Schultz and Roland Kr{\"a}mer",

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AU - Füssl, Andreas

AU - Schleifenbaum, Andreas

AU - Göritz, Mareike

AU - Riddell, Andrew

AU - Schultz, Carsten

AU - Krämer, Roland

PY - 2006/5/10

Y1 - 2006/5/10

N2 - Conjugation of usually impermeable peptide nucleic acids (PNA) to the chelator 2,2′:6′,2″-terpyridine strongly promotes cellular and nuclear uptake by cultured HeLa cells. Cellular accumulation is further enhanced in the presence of extracellular Zn2+.

AB - Conjugation of usually impermeable peptide nucleic acids (PNA) to the chelator 2,2′:6′,2″-terpyridine strongly promotes cellular and nuclear uptake by cultured HeLa cells. Cellular accumulation is further enhanced in the presence of extracellular Zn2+.

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Cellular uptake of PNA-terpyridine conjugates and its enhancement by Zn²⁺ ions

Abstract

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