Central and Hormonal Regulation of Renin Release by Baboon Kidneys

Virginia L. Brooks; Kyung Woo Cho; Richard L. Malvin; Bennett J. Cohen

doi:10.3181/00379727-165-40950

Central and Hormonal Regulation of Renin Release by Baboon Kidneys

Virginia L. Brooks, Kyung Woo Cho, Richard L. Malvin, Bennett J. Cohen

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Renin release from renal cortical slices of baboon kidneys was measured. It was found that the basal release rate was directly proportional to the renin content. Release was stimulated in a dose-dependent fashion by isoproterenol and was inhibited both by angiotensin II and vasopressin. Maximum inhibition was approximately 30%. Experiments also were done in which angiotensin II and converting enzyme inhibitor were infused into the lateral ventrical of anesthetized baboons. Angiotensin caused a reduction in plasma renin activity (PRA), and converting enzyme inhibitor an increase in PRA, independent of changes in blood pressure.

Original language	English (US)
Pages (from-to)	147-150
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	165
Issue number	1
DOIs	https://doi.org/10.3181/00379727-165-40950
State	Published - Oct 1980
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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author = "Brooks, {Virginia L.} and Cho, {Kyung Woo} and Malvin, {Richard L.} and Cohen, {Bennett J.}",

year = "1980",

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AU - Cho, Kyung Woo

AU - Malvin, Richard L.

AU - Cohen, Bennett J.

PY - 1980/10

Y1 - 1980/10

N2 - Renin release from renal cortical slices of baboon kidneys was measured. It was found that the basal release rate was directly proportional to the renin content. Release was stimulated in a dose-dependent fashion by isoproterenol and was inhibited both by angiotensin II and vasopressin. Maximum inhibition was approximately 30%. Experiments also were done in which angiotensin II and converting enzyme inhibitor were infused into the lateral ventrical of anesthetized baboons. Angiotensin caused a reduction in plasma renin activity (PRA), and converting enzyme inhibitor an increase in PRA, independent of changes in blood pressure.

AB - Renin release from renal cortical slices of baboon kidneys was measured. It was found that the basal release rate was directly proportional to the renin content. Release was stimulated in a dose-dependent fashion by isoproterenol and was inhibited both by angiotensin II and vasopressin. Maximum inhibition was approximately 30%. Experiments also were done in which angiotensin II and converting enzyme inhibitor were infused into the lateral ventrical of anesthetized baboons. Angiotensin caused a reduction in plasma renin activity (PRA), and converting enzyme inhibitor an increase in PRA, independent of changes in blood pressure.

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Central and Hormonal Regulation of Renin Release by Baboon Kidneys

Abstract

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