TY - JOUR
T1 - Central Corneal Thickness in Northwestern American Indians/Alaskan Natives and Comparison with White and African-American Persons
AU - Torres, Rodrigo J.
AU - Jones, Emily
AU - Edmunds, Beth
AU - Becker, Thomas
AU - Cioffi, George A.
AU - Mansberger, Steven L.
N1 - Funding Information:
This study was supported by Grant EY0155501-01 from the National Eye Institute, National Institutes of Health, Bethesda, Maryland (Dr Mansberger); the American Glaucoma Society, San Francisco, California (Dr Mansberger); Grant U48 DP000024-01 from the Centers for Disease Control and Prevention, Atlanta, Georgia (Dr Mansberger); and the Good Samaritan Foundation, Portland, Oregon. The authors indicate no financial conflict of interest. Involved in conception and design (S.L.M., B.E., E.J.); analysis and interpretation of data (R.J.T, S.L.M.); writing the manuscript (R.J.T., S.L.M.); review of manuscript (R.J.T., E.J., B.E., T.B., G.A.C., S.L.M.); final approval of manuscript (R.J.T., E.J., B.E., T.B., G.A.C., S.L.M.); collection of data (R.J.T., E.J., B.E., S.L.M.); statistical expertise (S.L.M.); obtaining funding (S.L.M., T.B., G.A.C.); and literature search (R.J.T., S.L.M., E.J.). Both Legacy Health System and the Northwest Portland Area Indian Health Board Institutional Review Boards approved this study. We obtained informed consent from all participants.
PY - 2008/11
Y1 - 2008/11
N2 - Purpose: To determine the demographic factors associated with central corneal thickness (CCT) in Northwestern American Indians/Alaskan Natives (AI/ANs) and to compare these CCT measurements with those of White and African-American persons. Design: Cross-sectional comparative, observational study. Methods: We performed ultrasonic pachymetry (DGH-500 Pachette; DGH Technologies, Exton, Pennsylvania, USA) on a random sample of AI/AN subjects from three randomly selected AI/AN tribes in the Northwest United States (n = 429). Pachymetry also was performed on a convenience sample of White (n = 46) and African-American (n = 33) persons. Our main outcome measure was the average of right and left eye CCT. Results: Average AI/AN CCT was 554.8 ± 33.9 μm. AI/AN CCT was found to be thicker than that of African Americans (528.5 ± 33.2 μm) but similar to that of White persons (551.9 ± 28.3 μm). CCT was greater in AI/AN females than in AI/AN males (557.6 ± 33.3 μm vs 550.1 ± 34.5 μm; P = .03). We found no difference in CCT based on percent AI/AN heritage, age, and keratometry readings. We found no significant differences in mean CCT between AI/ANs with glaucoma (556.2 μm) and those who did not have glaucoma (556.6 μm). Conclusions: CCT measurements for the Northwest AI/AN population are similar to those of White persons but thicker than those of African-American persons. Although glaucoma is common in AI/ANs, we did not find an association with thin CCT. We need future studies to explore the risk factors for glaucoma in AI/ANs.
AB - Purpose: To determine the demographic factors associated with central corneal thickness (CCT) in Northwestern American Indians/Alaskan Natives (AI/ANs) and to compare these CCT measurements with those of White and African-American persons. Design: Cross-sectional comparative, observational study. Methods: We performed ultrasonic pachymetry (DGH-500 Pachette; DGH Technologies, Exton, Pennsylvania, USA) on a random sample of AI/AN subjects from three randomly selected AI/AN tribes in the Northwest United States (n = 429). Pachymetry also was performed on a convenience sample of White (n = 46) and African-American (n = 33) persons. Our main outcome measure was the average of right and left eye CCT. Results: Average AI/AN CCT was 554.8 ± 33.9 μm. AI/AN CCT was found to be thicker than that of African Americans (528.5 ± 33.2 μm) but similar to that of White persons (551.9 ± 28.3 μm). CCT was greater in AI/AN females than in AI/AN males (557.6 ± 33.3 μm vs 550.1 ± 34.5 μm; P = .03). We found no difference in CCT based on percent AI/AN heritage, age, and keratometry readings. We found no significant differences in mean CCT between AI/ANs with glaucoma (556.2 μm) and those who did not have glaucoma (556.6 μm). Conclusions: CCT measurements for the Northwest AI/AN population are similar to those of White persons but thicker than those of African-American persons. Although glaucoma is common in AI/ANs, we did not find an association with thin CCT. We need future studies to explore the risk factors for glaucoma in AI/ANs.
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U2 - 10.1016/j.ajo.2008.05.047
DO - 10.1016/j.ajo.2008.05.047
M3 - Article
C2 - 18672219
AN - SCOPUS:54449087052
SN - 0002-9394
VL - 146
SP - 747-751.e2
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 5
ER -