Central nervous system circuits that control body temperature

Christopher J. Madden, Shaun F. Morrison

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations


Maintenance of mammalian core body temperature within a narrow range is a fundamental homeostatic process to optimize cellular and tissue function, and to improve survival in adverse thermal environments. Body temperature is maintained during a broad range of environmental and physiological challenges by central nervous system circuits that process thermal afferent inputs from the skin and the body core to control the activity of thermoeffectors. These include thermoregulatory behaviors, cutaneous vasomotion (vasoconstriction and, in humans, active vasodilation), thermogenesis (shivering and brown adipose tissue), evaporative heat loss (salivary spreading in rodents, and human sweating). This review provides an overview of the central nervous system circuits for thermoregulatory reflex regulation of thermoeffectors.

Original languageEnglish (US)
Pages (from-to)225-232
Number of pages8
JournalNeuroscience Letters
StatePublished - Mar 23 2019


  • Brown adipose tissue
  • Cutaneous vasomotion
  • Saliva secretion
  • Shivering
  • Sweating
  • Thermoregulation

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Central nervous system circuits that control body temperature'. Together they form a unique fingerprint.

Cite this