Abstract
Background: Stimulatory cerebellar TMS is a promising tool to improve motor control in neurodegenerative disorders. Objective/hypothesis: Our goal was to use 10Hz cerebellar rTMS to augment cerebellar-brain inhibition (CBI) for improved postural stability and speech in patients with progressive supranuclear palsy (PSP). Methods: We performed CBI assessments with neuronavigation before and after high frequency cerebellar rTMS or sham TMS in two patients with PSP, using a double cone coil for the conditioning pulse and a figure-of-eight coil for the test pulse and treatments. We collected posturography data and speech samples before and after treatment. Results: After treatment, CBI increased by 50% in subject 1 and by 32% in subject 2, and postural stability and speech improved. The protocol was well tolerated, but the sham was not consistently believable. Conclusion: Cerebellar rTMS may improve postural stability and speech in PSP, but cooled coils with vibrotactile sham capability are needed for larger future studies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1588-1591 |
| Number of pages | 4 |
| Journal | Brain Stimulation |
| Volume | 12 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1 2019 |
Keywords
- Balance
- Cerebellum
- Posturography
- Progressive supranuclear palsy
- Speech
- Transcranial magnetic stimulation
ASJC Scopus subject areas
- Biophysics
- Neuroscience(all)
- Clinical Neurology