TY - JOUR
T1 - Cerebrospinal fluid formation and absorption and transport of iodide and sulfate from the spinal subarachnoid space
AU - Lorenzo, A. V.
AU - Hammerstad, J. P.
AU - Cutler, R. W.P.
N1 - Funding Information:
Paper presented at a symposium on The Blood-Brain Barrier, held 11 September, 1968, in New York, N.Y. (U.S.A.). This study was supported by Grant NB15072 from the National Institute of Neurological Diseases and Blindness, U.S. Public Health Service. 1 Recipient of the Research Career Program Award from the National Advisory Neurological Diseases and Stroke Council, National Institute of Neurological Diseases and Stroke, Grant I-K4-NS-18,519-01 NSRB. Present address: Department of Neurology, University of Chicago, Chicago, Ill.
PY - 1970/3
Y1 - 1970/3
N2 - Numerous studies have demonstrated transport mechanisms within the cerebral ventricles which regulate the concentration of solutes within the cerebrospinal fluid (CSF) in vivo. Furthermore, studies of choroid plexus transport in vitro indicate that ependymal cells play a major role in these active regulatory mechanisms. Unfortunately, less attention has been given to the possibility that such mechanisms may exist in extraventricular compartments such as the spinal subarachnoid space (SSS). Ventriculo-lumbar, ventriculo-cisternal and cisternal-lumbar perfusions were performed in anesthetized cats to study bulk formation and absorption of spinal subarachnoid fluid (SSF), and the clearance of radioiodide and sulfate from the SSS. The results obtained are summarised in Table 4. Finally, the results indicate that non-ependymal tissues or cells are capable of actively transporting iodide from the SSF to blood. The probable locus of this transport mechanism and its relation to the "sink" hypothesis are discussed.
AB - Numerous studies have demonstrated transport mechanisms within the cerebral ventricles which regulate the concentration of solutes within the cerebrospinal fluid (CSF) in vivo. Furthermore, studies of choroid plexus transport in vitro indicate that ependymal cells play a major role in these active regulatory mechanisms. Unfortunately, less attention has been given to the possibility that such mechanisms may exist in extraventricular compartments such as the spinal subarachnoid space (SSS). Ventriculo-lumbar, ventriculo-cisternal and cisternal-lumbar perfusions were performed in anesthetized cats to study bulk formation and absorption of spinal subarachnoid fluid (SSF), and the clearance of radioiodide and sulfate from the SSS. The results obtained are summarised in Table 4. Finally, the results indicate that non-ependymal tissues or cells are capable of actively transporting iodide from the SSF to blood. The probable locus of this transport mechanism and its relation to the "sink" hypothesis are discussed.
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U2 - 10.1016/0022-510X(70)90153-X
DO - 10.1016/0022-510X(70)90153-X
M3 - Article
C2 - 5441553
AN - SCOPUS:0014759268
SN - 0022-510X
VL - 10
SP - 247
EP - 258
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
IS - 3
ER -