Cerebrospinal fluid hormone concentration in the evaluation of pituitary tumors

R. M. Jordan, J. W. Kendall, J. L. Seaich, J. P. Allen, C. A. Paulsen, C. W. Kerber, W. P. Vanderlaan

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Cerebrospinal fluid (CSF) concentrations of corticotropin, growth hormone, thyrotropin, prolactin, luteinizing hormone, and follicle stimulating hormone were measured in 28 patients with various neurologic disorders, in 49 patients with pituitary tumors of whom 22 had suprasellar extension, and in 6 patients with craniopharyngiomas. With the exception of 1 patient with pseudotumor cerebri, CSF adenohypophyseal hormone concentrations were low in patients with neurologic disease and in patients with pituitary tumor without suprasellar extension. In marked contrast, 21 of 22 patients with suprasellar extension of a pituitary tumor and 2 of 6 patients with a craniopharyngioma had elevations of one or more CSF adenohypophyseal hormones. Posttreatment CSF adenohypophyseal hormone levels fell from previously elevated levels in 4 of 5 patients. These data suggest that an elevated CSF adenohypophyseal hormone concentration is a sensitive indicator of suprasellar extension of a pituitary tumor, and posttreatment measurements are useful in determining efficacy of therapy.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalUnknown Journal
Issue number1
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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