Challenges and opportunities for modeling aging and cancer

Olga Anczuków; Susie Airhart; Jeffrey H. Chuang; Lisa M. Coussens; George A. Kuchel; Ron Korstanje; Sheng Li; Anna Lisa Lucido; Sandra S. McAllister; Katerina Politi; Kornelia Polyak; Timothy Ratliff; Gary Ren; Jennifer J. Trowbridge; Duygu Ucar; Karolina Palucka

doi:10.1016/j.ccell.2023.03.006

Challenges and opportunities for modeling aging and cancer

Olga Anczuków, Susie Airhart, Jeffrey H. Chuang, Lisa M. Coussens, George A. Kuchel, Ron Korstanje, Sheng Li, Anna Lisa Lucido, Sandra S. McAllister, Katerina Politi, Kornelia Polyak, Timothy Ratliff, Gary Ren, Jennifer J. Trowbridge, Duygu Ucar, Karolina Palucka

Cell Developmental and Cancer Biology

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet, pre-clinical studies are carried out using young mice and are not able to address the impact of aging and associated comorbidities on disease biology and treatment outcomes. Here, we discuss the limitations of current mouse cancer models and suggest strategies for developing novel models to address these major gaps in knowledge and experimental approaches.

Original language	English (US)
Pages (from-to)	641-645
Number of pages	5
Journal	Cancer Cell
Volume	41
Issue number	4
DOIs	https://doi.org/10.1016/j.ccell.2023.03.006
State	Published - Apr 10 2023

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Challenges and opportunities for modeling aging and cancer",

abstract = "Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet, pre-clinical studies are carried out using young mice and are not able to address the impact of aging and associated comorbidities on disease biology and treatment outcomes. Here, we discuss the limitations of current mouse cancer models and suggest strategies for developing novel models to address these major gaps in knowledge and experimental approaches.",

author = "Olga Anczuk{\'o}w and Susie Airhart and Chuang, {Jeffrey H.} and Coussens, {Lisa M.} and Kuchel, {George A.} and Ron Korstanje and Sheng Li and Lucido, {Anna Lisa} and McAllister, {Sandra S.} and Katerina Politi and Kornelia Polyak and Timothy Ratliff and Gary Ren and Trowbridge, {Jennifer J.} and Duygu Ucar and Karolina Palucka",

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doi = "10.1016/j.ccell.2023.03.006",

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TY - JOUR

T1 - Challenges and opportunities for modeling aging and cancer

AU - Anczuków, Olga

AU - Airhart, Susie

AU - Chuang, Jeffrey H.

AU - Coussens, Lisa M.

AU - Kuchel, George A.

AU - Korstanje, Ron

AU - Li, Sheng

AU - Lucido, Anna Lisa

AU - McAllister, Sandra S.

AU - Politi, Katerina

AU - Polyak, Kornelia

AU - Ratliff, Timothy

AU - Ren, Gary

AU - Trowbridge, Jennifer J.

AU - Ucar, Duygu

AU - Palucka, Karolina

PY - 2023/4/10

Y1 - 2023/4/10

N2 - Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet, pre-clinical studies are carried out using young mice and are not able to address the impact of aging and associated comorbidities on disease biology and treatment outcomes. Here, we discuss the limitations of current mouse cancer models and suggest strategies for developing novel models to address these major gaps in knowledge and experimental approaches.

AB - Age is among the main risk factors for cancer, and any cancer study in adults is faced with an aging tissue and organism. Yet, pre-clinical studies are carried out using young mice and are not able to address the impact of aging and associated comorbidities on disease biology and treatment outcomes. Here, we discuss the limitations of current mouse cancer models and suggest strategies for developing novel models to address these major gaps in knowledge and experimental approaches.

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U2 - 10.1016/j.ccell.2023.03.006

DO - 10.1016/j.ccell.2023.03.006

M3 - Comment/debate

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AN - SCOPUS:85151502879

SN - 1535-6108

VL - 41

SP - 641

EP - 645

JO - Cancer Cell

JF - Cancer Cell

IS - 4

ER -

Challenges and opportunities for modeling aging and cancer

Abstract

ASJC Scopus subject areas

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