Change in general and central adiposity measures in prediction of incident dysglycemia; Tehran Lipid and Glucose Study

Farzad Hadaegh, Younes Jahangiri Noudeh, Maryam Tohidi, Nasibeh Vatankhah, Davood Khalili, Reza Mohebi, Fereidoun Azizi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objectives: To examine the change in general and central adiposity measures as a predictor of incident dysglycemia during a 6-year follow-up. Subjects: A total of 4029 (2333 women and 1696 men) non-dysglycemic Iranians aged ≥ 20. years, underwent standard fasting and 2-h post-challenge plasma glucose tests at baseline and follow-up. Results: During follow-up, 458 new cases of dysglycemia occurred. In multivariable models including baseline values of each anthropometric measure, odds ratios (ORs) for dysglycemia incidence corresponding to a 1-SD increase in changes of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and hip circumference (HC), were 1.32, 1.56, 1.39, 1.51 and 1.39 for men and 1.59, 1.50, 1.37, 1.47, and 1.38, for women, respectively (all P< 0.05). After controlling for weight change and WC change among men and women, respectively, HC change did not remain as a predictor. Using the paired homogeneity test, there was no superiority for changes in central obesity measures compared to changes in BMI to predict dysglycemia. Conclusion: The association between HC changes and incident dysglycemia was dependent upon changes in central and general adiposity measures, where the former did not have higher predictability than the latter in prediction of dysglycemia.

Original languageEnglish (US)
Pages (from-to)608-612
Number of pages5
JournalPreventive medicine
Issue number6
StatePublished - Dec 2012
Externally publishedYes


  • BMI change
  • Height change
  • Hip circumference change
  • Incident dysglycemia
  • Waist circumference change
  • Waist-to-height ratio change
  • Waist-to-hip ratio change
  • Weight change

ASJC Scopus subject areas

  • Epidemiology
  • Public Health, Environmental and Occupational Health


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