Chapter 1.3 Gene targeted animals with alterations in corticotropin pathways: new insights into allostatic control

Sarah C. Coste, Susan E. Murray, Mary P. Stenzel-Poore

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


The corticotropin-releasing factor (CRF) family constitutes a primary system that mediates adaptive neuroendocrine, autonomic, and behavioral responses to stress, a process known as allostasis. Genetically engineered mice provide a powerful tool for dissection of corticotropin pathways. A collection of models have been generated that harbor specific alterations in ligands, receptors, and the binding protein. In this review, we describe prominent neuroendocrine and behavioral features of these genetic mouse models that have led to new insights of allostatic regulation and associated pathology.

Original languageEnglish (US)
Title of host publicationTechniques in the Behavioral and Neural Sciences
PublisherAcademic Press
Number of pages24
EditionPART 2
StatePublished - 2005

Publication series

NameTechniques in the Behavioral and Neural Sciences
NumberPART 2
ISSN (Print)0921-0709


  • ACTH
  • AVP
  • Adrenocorticotropin hormone
  • Arginine vasopression
  • BNST
  • Bed nucleus of the stria terminalis
  • CNS
  • CRF
  • CRF binding protein
  • CRF receptor type 1
  • CRF receptor type 2
  • CRF-BP
  • Central nervous system
  • Corticotropin-releasing factor
  • GR
  • Glucocorticoid receptor
  • Glycoprotein hormone α-subunit
  • HPA
  • Hypothalamic-pituitary-adrenal axis
  • IL-6
  • Interleukin 6
  • Intracerebroventricular
  • KO
  • Knockout
  • LPS
  • Lipopolysaccharide
  • MR
  • Metallothionein
  • Mineralocorticoid receptor
  • NTS
  • Nucleus of the solitary tract
  • PNMT
  • POMC
  • PVN
  • Paraventricular nucleus of the hypothalamus
  • Phenylethanolamine N-methyltransferase
  • Tg
  • Transgenic
  • VMH
  • Ventromedial hypothalamus
  • WT
  • Wild-type
  • YAC
  • Yeast artificial chromosome
  • icv
  • mMT
  • pro-opiomelanocortin
  • α-GSU

ASJC Scopus subject areas

  • Behavioral Neuroscience


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