TY - GEN
T1 - Characterization of lymph node optical properties for phantom fabrication
AU - Torres, Veronica C.
AU - Wilson, Todd
AU - Li, Chengyue
AU - Sinha, Lagnojita
AU - Brankov, Jovan G.
AU - Tichauer, Kenneth M.
N1 - Publisher Copyright:
© 2019 SPIE.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Sentinel lymph node biopsy is a primary mean of staging cancer; however, the time-intensive nature of standard pathology limits the volume of the node that can be assessed. As a result, micrometastases can be missed, which have been shown to affect treatment decisions and therefore clinical outcomes. Optical imaging offers a potential solution for improved sensitivity and larger tissue evaluation, but an understanding of optical properties is necessary because of the high scattering nature of biological tissue. Here, time-domain optical imaging and measures of transmittance are used to characterize the optical properties of porcine lymph nodes at 685 nm and 780 nm. Results demonstrated values comparable to that of other soft biological tissue (685 nm: μa = 0.09 ± 0.01cm-1, μs' = 2.60 ± 0.42 cm-1, g = 0.95; 780 nm: μa = 0.24 ± 0.10cm-1, μs' = 3.35 ± 0.14 cm-1, g = 0.92). Based on these coefficients, optical properties of TiO2 were investigated so that a protocol to fabricate a lymph node tissue-mimicking phantom could be defined.
AB - Sentinel lymph node biopsy is a primary mean of staging cancer; however, the time-intensive nature of standard pathology limits the volume of the node that can be assessed. As a result, micrometastases can be missed, which have been shown to affect treatment decisions and therefore clinical outcomes. Optical imaging offers a potential solution for improved sensitivity and larger tissue evaluation, but an understanding of optical properties is necessary because of the high scattering nature of biological tissue. Here, time-domain optical imaging and measures of transmittance are used to characterize the optical properties of porcine lymph nodes at 685 nm and 780 nm. Results demonstrated values comparable to that of other soft biological tissue (685 nm: μa = 0.09 ± 0.01cm-1, μs' = 2.60 ± 0.42 cm-1, g = 0.95; 780 nm: μa = 0.24 ± 0.10cm-1, μs' = 3.35 ± 0.14 cm-1, g = 0.92). Based on these coefficients, optical properties of TiO2 were investigated so that a protocol to fabricate a lymph node tissue-mimicking phantom could be defined.
KW - Lymph node
KW - Optical properties
KW - Phantom
KW - Time domain
UR - https://www.scopus.com/pages/publications/85064408642
UR - https://www.scopus.com/pages/publications/85064408642#tab=citedBy
U2 - 10.1117/12.2513245
DO - 10.1117/12.2513245
M3 - Conference contribution
AN - SCOPUS:85064408642
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII
A2 - Grundfest, Warren S.
A2 - Mahadevan-Jansen, Anita
PB - SPIE
T2 - Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XVII 2019
Y2 - 3 February 2019 through 5 February 2019
ER -