Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation

Kelli M. Williams; Abby L. Dotson; Amber R. Otto; Jacob E. Kohlmeier; Stephen H. Benedict

doi:10.1016/j.cellimm.2011.08.010

Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation

Kelli M. Williams
, Abby L. Dotson
, Amber R. Otto
, Jacob E. Kohlmeier
, Stephen H. Benedict

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

With antigen stimulation, naïve CD4+ T cells differentiate to several effector or memory cell populations, and cytokines contribute to differentiation outcome. Several proteins on these cells receive costimulatory signals, but a systematic comparison of their differential effects on naïve T cell differentiation has not been conducted. Two costimulatory proteins, CD28 and ICAM-1, resident on human naïve CD4+ T cells were compared for participation in differentiation. Under controlled conditions, and with no added cytokines, costimulation through either CD3+CD28 or CD3+CAM-1 induced differentiation to T effector and T memory cells. In contrast, costimulation through CD3+ICAM-1 induced differentiation to Treg cells whereas costimulation through CD3+CD28 did not.

Original language	English (US)
Pages (from-to)	418-427
Number of pages	10
Journal	Cellular Immunology
Volume	271
Issue number	2
DOIs	https://doi.org/10.1016/j.cellimm.2011.08.010
State	Published - 2011
Externally published	Yes

Funding

The authors thank Dr. T. Yankee for critical reading of the manuscript, Dr. M. Chan, Dr. T. Yankee, Dr. C. Rockwell and Dr. C. Vines for helpful discussion during the course of this study, G. Haslam for technical assistance and L. Kimble for phlebotomy. This work was supported by AG023946 from the National Institute on Aging and DK073119 from the National Institute of Diabetes and Digestive and Kidney Diseases .

Funders	Funder number
National Institute of Aging	R03AG023946
National Institute of Diabetes and Digestive and Kidney Diseases	R21DK073119

Keywords

CD28
Costimulation
Foxp3
ICAM-1
Naïve T cell differentiation
Regulatory T cells

ASJC Scopus subject areas

Immunology

Access to Document

10.1016/j.cellimm.2011.08.010

Cite this

@article{d5dec65e481d46edbce5d4c9a9ea39e0,

title = "Choice of resident costimulatory molecule can influence cell fate in human na{\"i}ve CD4+ T cell differentiation",

abstract = "With antigen stimulation, na{\"i}ve CD4+ T cells differentiate to several effector or memory cell populations, and cytokines contribute to differentiation outcome. Several proteins on these cells receive costimulatory signals, but a systematic comparison of their differential effects on na{\"i}ve T cell differentiation has not been conducted. Two costimulatory proteins, CD28 and ICAM-1, resident on human na{\"i}ve CD4+ T cells were compared for participation in differentiation. Under controlled conditions, and with no added cytokines, costimulation through either CD3+CD28 or CD3+CAM-1 induced differentiation to T effector and T memory cells. In contrast, costimulation through CD3+ICAM-1 induced differentiation to Treg cells whereas costimulation through CD3+CD28 did not.",

keywords = "CD28, Costimulation, Foxp3, ICAM-1, Na{\"i}ve T cell differentiation, Regulatory T cells",

author = "Williams, \{Kelli M.\} and Dotson, \{Abby L.\} and Otto, \{Amber R.\} and Kohlmeier, \{Jacob E.\} and Benedict, \{Stephen H.\}",

note = "Funding Information: The authors thank Dr. T. Yankee for critical reading of the manuscript, Dr. M. Chan, Dr. T. Yankee, Dr. C. Rockwell and Dr. C. Vines for helpful discussion during the course of this study, G. Haslam for technical assistance and L. Kimble for phlebotomy. This work was supported by AG023946 from the National Institute on Aging and DK073119 from the National Institute of Diabetes and Digestive and Kidney Diseases .",

year = "2011",

doi = "10.1016/j.cellimm.2011.08.010",

language = "English (US)",

volume = "271",

pages = "418--427",

journal = "Cellular Immunology",

issn = "0008-8749",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation

AU - Williams, Kelli M.

AU - Dotson, Abby L.

AU - Otto, Amber R.

AU - Kohlmeier, Jacob E.

AU - Benedict, Stephen H.

N1 - Funding Information: The authors thank Dr. T. Yankee for critical reading of the manuscript, Dr. M. Chan, Dr. T. Yankee, Dr. C. Rockwell and Dr. C. Vines for helpful discussion during the course of this study, G. Haslam for technical assistance and L. Kimble for phlebotomy. This work was supported by AG023946 from the National Institute on Aging and DK073119 from the National Institute of Diabetes and Digestive and Kidney Diseases .

PY - 2011

Y1 - 2011

N2 - With antigen stimulation, naïve CD4+ T cells differentiate to several effector or memory cell populations, and cytokines contribute to differentiation outcome. Several proteins on these cells receive costimulatory signals, but a systematic comparison of their differential effects on naïve T cell differentiation has not been conducted. Two costimulatory proteins, CD28 and ICAM-1, resident on human naïve CD4+ T cells were compared for participation in differentiation. Under controlled conditions, and with no added cytokines, costimulation through either CD3+CD28 or CD3+CAM-1 induced differentiation to T effector and T memory cells. In contrast, costimulation through CD3+ICAM-1 induced differentiation to Treg cells whereas costimulation through CD3+CD28 did not.

AB - With antigen stimulation, naïve CD4+ T cells differentiate to several effector or memory cell populations, and cytokines contribute to differentiation outcome. Several proteins on these cells receive costimulatory signals, but a systematic comparison of their differential effects on naïve T cell differentiation has not been conducted. Two costimulatory proteins, CD28 and ICAM-1, resident on human naïve CD4+ T cells were compared for participation in differentiation. Under controlled conditions, and with no added cytokines, costimulation through either CD3+CD28 or CD3+CAM-1 induced differentiation to T effector and T memory cells. In contrast, costimulation through CD3+ICAM-1 induced differentiation to Treg cells whereas costimulation through CD3+CD28 did not.

KW - CD28

KW - Costimulation

KW - Foxp3

KW - ICAM-1

KW - Naïve T cell differentiation

KW - Regulatory T cells

UR - https://www.scopus.com/pages/publications/80054014387

UR - https://www.scopus.com/pages/publications/80054014387#tab=citedBy

U2 - 10.1016/j.cellimm.2011.08.010

DO - 10.1016/j.cellimm.2011.08.010

M3 - Article

C2 - 21943647

AN - SCOPUS:80054014387

SN - 0008-8749

VL - 271

SP - 418

EP - 427

JO - Cellular Immunology

JF - Cellular Immunology

IS - 2

ER -

Choice of resident costimulatory molecule can influence cell fate in human naïve CD4+ T cell differentiation

Abstract

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this