Chromatin alteration, transcription and replication: What's the opening line to the story?

Michelle Craig Barton, Alison J. Crowe

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Polymerase accessibility to chromatin is a limiting step in both RNA and DNA synthesis. Unwinding DNA and nucleosomes during polymerase complex binding and processing likely requires priming by chromatin restructuring. The initiating step in these processes remains an area of speculation. This review focuses on the physical handling of chromatin during transcription and replication, the fate of nucleosomes assembled on DNA during unwinding and processing the chromatin substrate, and how these alterations in chromatin structure may affect gene expression. Transcription or replication may alter chromatin structure during synthesis, enabling regulatory factor binding and, potentially, future rounds of transcription. As chromatin remodeling and transcription factor binding augment transcription and replication, and are themselves increased by these processes, a temporal model of structural alterations and gene activation is built that may be more circular than linear.

Original languageEnglish (US)
Pages (from-to)3094-3099
Number of pages6
Issue number24 REV. ISS. 3
StatePublished - May 28 2001
Externally publishedYes


  • Chromatin
  • Polymerase
  • Remodeling
  • Replication
  • Transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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