Chronic alcohol self-administration in monkeys shows long-term quantity/frequency categorical stability

Erich J. Baker, Jonathan Farro, Steven Gonzales, Christa Helms, Kathleen A. Grant

Research output: Contribution to journalArticlepeer-review

67 Scopus citations


Background: The current criteria for alcohol use disorders (AUDs) do not include consumption (quantity/frequency) measures of alcohol intake, in part due to the difficulty of these measures in humans. Animal models of ethanol (EtOH) self-administration have been fundamental in advancing our understanding of the neurobiological basis of AUD and can address quantity/frequency measures with accurate measurements over prolonged periods of time. The nonhuman primate model of voluntary oral alcohol self-administration has documented both binge drinking and drinking to dependence and can be used to test the stability of consumption measures over time. Methods: Here, an extensive set of alcohol intakes (g/kg/d) was analyzed from a large multi-cohort population of Rhesus (Macaca mulatta) monkeys (n = 31). Daily EtOH intake was uniformly distributed over chronic (12 months) access for all animals. Results: Underlying this distribution of intakes were subpopulations of monkeys that exhibited distinctive clustering of drinking patterns, allowing us to categorically define very heavy drinking (VHD), heavy drinking (HD), binge drinking (BD), and low drinking (LD). These categories were stable across the 12 months assessed by the protocol, but exhibited fluctuations when examined at shorter intervals. Conclusions: The establishment of persistent drinking categories based on quantity/frequency suggests that consumption variables can be used to track long-term changes in behavioral, molecular, or physiochemical mechanisms related to our understanding of diagnosis, prevention, intervention, and treatment efficacies.

Original languageEnglish (US)
Pages (from-to)2835-2843
Number of pages9
JournalAlcoholism: Clinical and Experimental Research
Issue number11
StatePublished - Nov 1 2014


  • Alcohol
  • Binge drinking
  • EtOH
  • Nonhuman primates
  • Self-administration

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health


Dive into the research topics of 'Chronic alcohol self-administration in monkeys shows long-term quantity/frequency categorical stability'. Together they form a unique fingerprint.

Cite this