Chronic treatment with vasopressin analogues alters affinity of vasopressin receptors in the septum and amygdala of the rat brain

Michael W. Swank; Daniel M. Dorsa

doi:10.1016/0006-8993(91)90077-9

Chronic treatment with vasopressin analogues alters affinity of vasopressin receptors in the septum and amygdala of the rat brain

Michael W. Swank, Daniel M. Dorsa

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Accurel devices were used to administer AVP or AVP-antagonist into the lateral ventricle of the rat brain for 7 days. Neither AVP nor antagonist altered total binding site concentration in either septum or amygdala. However, treatment with antagonist caused a marked decrease in the affinity of the receptor for agonist in both the septum and amygdala.

Original language	English (US)
Pages (from-to)	342-344
Number of pages	3
Journal	Brain research
Volume	544
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(91)90077-9
State	Published - Mar 29 1991
Externally published	Yes

Keywords

Accurel colloidion device
Antagonist
Brain
Vasopressin receptor

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)90077-9

Cite this

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title = "Chronic treatment with vasopressin analogues alters affinity of vasopressin receptors in the septum and amygdala of the rat brain",

abstract = "Accurel devices were used to administer AVP or AVP-antagonist into the lateral ventricle of the rat brain for 7 days. Neither AVP nor antagonist altered total binding site concentration in either septum or amygdala. However, treatment with antagonist caused a marked decrease in the affinity of the receptor for agonist in both the septum and amygdala.",

keywords = "Accurel colloidion device, Antagonist, Brain, Vasopressin receptor",

author = "Swank, {Michael W.} and Dorsa, {Daniel M.}",

note = "Funding Information: 10 Kruisbrink, J., Van der Woude, T.E, Boer, G.J. and Mirmiran, M., Manipulation of vasopressin level in the cerebrospinal fluid of the rat by means of an easily interchangeable controlled-delivery Accurel mini-device, J. Neurosci. Methods, 17 (1986) These studies were supported by NIH Grant NS20311, Institutional Grant for Neurobiology T32GM07108, and by the research service of the Department of Veterans Affairs.",

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doi = "10.1016/0006-8993(91)90077-9",

language = "English (US)",

volume = "544",

pages = "342--344",

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T1 - Chronic treatment with vasopressin analogues alters affinity of vasopressin receptors in the septum and amygdala of the rat brain

AU - Swank, Michael W.

AU - Dorsa, Daniel M.

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PY - 1991/3/29

Y1 - 1991/3/29

N2 - Accurel devices were used to administer AVP or AVP-antagonist into the lateral ventricle of the rat brain for 7 days. Neither AVP nor antagonist altered total binding site concentration in either septum or amygdala. However, treatment with antagonist caused a marked decrease in the affinity of the receptor for agonist in both the septum and amygdala.

AB - Accurel devices were used to administer AVP or AVP-antagonist into the lateral ventricle of the rat brain for 7 days. Neither AVP nor antagonist altered total binding site concentration in either septum or amygdala. However, treatment with antagonist caused a marked decrease in the affinity of the receptor for agonist in both the septum and amygdala.

KW - Accurel colloidion device

KW - Antagonist

KW - Brain

KW - Vasopressin receptor

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ER -

Chronic treatment with vasopressin analogues alters affinity of vasopressin receptors in the septum and amygdala of the rat brain

Abstract

Keywords

ASJC Scopus subject areas

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