Circadian Function and Therapeutic Potential of Melatonin in Humans

A. J. Lewy; J. Songer; K. Yuhas; J. S. Emens

doi:10.1016/B978-008045046-9.01618-1

Circadian Function and Therapeutic Potential of Melatonin in Humans

A. J. Lewy, J. Songer, K. Yuhas, J. S. Emens

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

A primary role for melatonin relates to the human circadian system. Endogenous melatonin production is the ideal marker for biological time. Its physiological function in humans probably relates to the fact that low physiological doses of melatonin cause phase advances when administered in the morning and cause phase delays when administered in the afternoon/evening, the treatment of choice for free-running totally blind people. Bright light, the treatment of choice for circadian abnormalities in sighted people, causes phase advances when scheduled in the morning and phase delays when scheduled in the evening. Future interest in this area is expected to markedly increase.

Original language	English (US)
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd
Pages	893-900
Number of pages	8
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.01618-1
State	Published - 2009

Keywords

Blind free-runners (BFRs)
Circadian alignment/misalignment
Circadian period (tau)
Circadian time (CT)
Dim light melatonin onset (DLMO)
Entrainment
Light
Melatonin
Melatonin suppression test (MST)
Phase advance
Phase angle difference (PAD)
Phase angle of entrainment (PAE)
Phase delay
Phase response curve (PRC)
Pineal gland
Relative coordination
Seasonal affective disorder (SAD)
Zeitgeber time (ZT)

ASJC Scopus subject areas

General Neuroscience

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10.1016/B978-008045046-9.01618-1

Cite this

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title = "Circadian Function and Therapeutic Potential of Melatonin in Humans",

abstract = "A primary role for melatonin relates to the human circadian system. Endogenous melatonin production is the ideal marker for biological time. Its physiological function in humans probably relates to the fact that low physiological doses of melatonin cause phase advances when administered in the morning and cause phase delays when administered in the afternoon/evening, the treatment of choice for free-running totally blind people. Bright light, the treatment of choice for circadian abnormalities in sighted people, causes phase advances when scheduled in the morning and phase delays when scheduled in the evening. Future interest in this area is expected to markedly increase.",

keywords = "Blind free-runners (BFRs), Circadian alignment/misalignment, Circadian period (tau), Circadian time (CT), Dim light melatonin onset (DLMO), Entrainment, Light, Melatonin, Melatonin suppression test (MST), Phase advance, Phase angle difference (PAD), Phase angle of entrainment (PAE), Phase delay, Phase response curve (PRC), Pineal gland, Relative coordination, Seasonal affective disorder (SAD), Zeitgeber time (ZT)",

author = "Lewy, {A. J.} and J. Songer and K. Yuhas and Emens, {J. S.}",

year = "2009",

doi = "10.1016/B978-008045046-9.01618-1",

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T1 - Circadian Function and Therapeutic Potential of Melatonin in Humans

AU - Lewy, A. J.

AU - Songer, J.

AU - Yuhas, K.

AU - Emens, J. S.

PY - 2009

Y1 - 2009

N2 - A primary role for melatonin relates to the human circadian system. Endogenous melatonin production is the ideal marker for biological time. Its physiological function in humans probably relates to the fact that low physiological doses of melatonin cause phase advances when administered in the morning and cause phase delays when administered in the afternoon/evening, the treatment of choice for free-running totally blind people. Bright light, the treatment of choice for circadian abnormalities in sighted people, causes phase advances when scheduled in the morning and phase delays when scheduled in the evening. Future interest in this area is expected to markedly increase.

AB - A primary role for melatonin relates to the human circadian system. Endogenous melatonin production is the ideal marker for biological time. Its physiological function in humans probably relates to the fact that low physiological doses of melatonin cause phase advances when administered in the morning and cause phase delays when administered in the afternoon/evening, the treatment of choice for free-running totally blind people. Bright light, the treatment of choice for circadian abnormalities in sighted people, causes phase advances when scheduled in the morning and phase delays when scheduled in the evening. Future interest in this area is expected to markedly increase.

KW - Blind free-runners (BFRs)

KW - Circadian alignment/misalignment

KW - Circadian period (tau)

KW - Circadian time (CT)

KW - Dim light melatonin onset (DLMO)

KW - Entrainment

KW - Light

KW - Melatonin

KW - Melatonin suppression test (MST)

KW - Phase advance

KW - Phase angle difference (PAD)

KW - Phase angle of entrainment (PAE)

KW - Phase delay

KW - Phase response curve (PRC)

KW - Pineal gland

KW - Relative coordination

KW - Seasonal affective disorder (SAD)

KW - Zeitgeber time (ZT)

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DO - 10.1016/B978-008045046-9.01618-1

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AN - SCOPUS:84882827229

SN - 9780080450469

SP - 893

EP - 900

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -

Circadian Function and Therapeutic Potential of Melatonin in Humans

Abstract

Keywords

ASJC Scopus subject areas

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