Circadian variation in the physiology and behavior of humans and nonhuman primates

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Scopus citations

Abstract

The rhesus macaque represents a pragmatic animal model for elucidating mechanisms underlying normal and pathological human behaviors. Many of the same techniques that are used in clinical studies can be readily applied to the nonhuman primate studies. These including the use of Actiwatch recorders for monitoring of 24-h activity-rest cycles and the use of a remote blood sample collection system for assessment of changes in circadian hormone profiles. In addition, comprehensive rhesus macaque gene microarrays (Affymetrix) are now commercially available, and these can be used for profiling gene expression changes under various physiological and pathological conditions. Our recent application of these methodologies to rhesus macaque studies emphasizes that many physiological and behavioral events, and the expression of associated genes, have a distinct 24-h expression pattern. Consequently, it is important to take these circadian rhythms into account when designing experiments and interpreting the results.

Original languageEnglish (US)
Title of host publicationAnimal Models of Behavioral Analysis
EditorsJacob Raber
Pages217-235
Number of pages19
DOIs
StatePublished - 2011

Publication series

NameNeuromethods
Volume50
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • Circadian rhythms
  • DHEAS
  • cortisol
  • gene microarrays
  • photoperiod
  • sleep

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

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