Circadian variation in ventricular electrical instability associated with coronary artery disease

James McClelland, Blair Halperin, Joel Cutler, Peter Kudenchuk, Jack Kron, John McAnulty

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Although sudden cardiac deaths and ischemic cardiac events clearly occur in a circadian pattern, such a pattern has not been shown for primary arrhythmic events. Because primary arrhythmic events are thought to play an Important role in sudden cardiac death, a large series of ventricular stimulation studies was analyzed to determine whether circadian variation in ventricular electrical instability exists. If such a circadian variation could be shown, it could have implications for the conduct and interpretation of electrophysiologic testing and the etiology of circadian variation in sudden cardiac death. Results of 2 drug-free ventricular stimulation studies performed 4 to 28 hours apart in each of 162 patients with coronary artery disease were analyzed. Rate and duration of Induced arrhythmia, number of extrastimui required to Induce arrhythmia and changes in these factors between the 2 tests in each patient were analyzed. Comparisons were made by half-day, by hour and in a temporally continuous manner to eliminate errors associated with any single method. No significant circadian variation was found in any electrophysiologic measure of ventricular electrical instability despite adequate statistical power. These findings show that the time of day during which ventricular stimulation tests are performed does not affect test results, and therefore does not need to be controlled during electrophysiologic studies. If these findings are parallel to those in ambulatory patients with coronary artery disease, then circadian changes in ventricular electrical instability may not play as important a role in the circadian pattern of sudden cardiac death as had been previously thought.

Original languageEnglish (US)
Pages (from-to)1351-1357
Number of pages7
JournalThe American journal of cardiology
Issue number20
StatePublished - Jun 1 1990

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Circadian variation in ventricular electrical instability associated with coronary artery disease'. Together they form a unique fingerprint.

Cite this