Classification of Chronic Rhinosinusitis—Working Toward Personalized Diagnosis

Adam S. DeConde; Timothy L. Smith

doi:10.1016/j.otc.2016.08.003

Classification of Chronic Rhinosinusitis—Working Toward Personalized Diagnosis

Adam S. DeConde, Timothy L. Smith

Otolaryngology

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

An estimated 4.5% of total US health care dollars have been devoted to mitigating chronic rhinosinusitis. The most recalcitrant of these patients undergo surgery, which fails to improve symptoms in approximately 25% of patients. Recent advances in informational, microbiomic, and genomic analysis have introduced the first set of tools that patients, physicians, politicians, and payers can apply to better forecast which patients will respond favorably to endoscopic sinus surgery. This article summarizes the forces driving the application of personalized medicine to CRS and how new advances can be applied to clinical practice.

Original language	English (US)
Pages (from-to)	1-12
Number of pages	12
Journal	Otolaryngologic Clinics of North America
Volume	50
Issue number	1
DOIs	https://doi.org/10.1016/j.otc.2016.08.003
State	Published - Feb 1 2017

Keywords

Chronic rhinosinusitis
Cluster analysis
Endotype
Epidemiology
Microbiome
Personalized medicine
Phenotype
Precision medicine

ASJC Scopus subject areas

Otorhinolaryngology

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10.1016/j.otc.2016.08.003

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abstract = "An estimated 4.5% of total US health care dollars have been devoted to mitigating chronic rhinosinusitis. The most recalcitrant of these patients undergo surgery, which fails to improve symptoms in approximately 25% of patients. Recent advances in informational, microbiomic, and genomic analysis have introduced the first set of tools that patients, physicians, politicians, and payers can apply to better forecast which patients will respond favorably to endoscopic sinus surgery. This article summarizes the forces driving the application of personalized medicine to CRS and how new advances can be applied to clinical practice.",

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note = "Funding Information: Financial Disclosures: A.S. DeConde and T.L. Smith are consultants for IntersectENT, Incorporated (Menlo Park, California), which is not affiliated with this article. T.L. Smith is supported by a grant for this investigation from the National Institute on Deafness and Other Communication Disorders (NIDCD) , one of the National Institutes of Health, Bethesda, Maryland ( R01 DC005805 ; PI/PD: T.L. Smith). Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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AU - Smith, Timothy L.

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KW - Chronic rhinosinusitis

KW - Cluster analysis

KW - Endotype

KW - Epidemiology

KW - Microbiome

KW - Personalized medicine

KW - Phenotype

KW - Precision medicine

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Classification of Chronic Rhinosinusitis—Working Toward Personalized Diagnosis

Abstract

Keywords

ASJC Scopus subject areas

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