Classification of Chronic Rhinosinusitis—Working Toward Personalized Diagnosis

Adam S. DeConde, Timothy L. Smith

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


An estimated 4.5% of total US health care dollars have been devoted to mitigating chronic rhinosinusitis. The most recalcitrant of these patients undergo surgery, which fails to improve symptoms in approximately 25% of patients. Recent advances in informational, microbiomic, and genomic analysis have introduced the first set of tools that patients, physicians, politicians, and payers can apply to better forecast which patients will respond favorably to endoscopic sinus surgery. This article summarizes the forces driving the application of personalized medicine to CRS and how new advances can be applied to clinical practice.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalOtolaryngologic Clinics of North America
Issue number1
StatePublished - Feb 1 2017


  • Chronic rhinosinusitis
  • Cluster analysis
  • Endotype
  • Epidemiology
  • Microbiome
  • Personalized medicine
  • Phenotype
  • Precision medicine

ASJC Scopus subject areas

  • Otorhinolaryngology


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