Clear cell odontogenic carcinoma: Report of a case and analysis of the literature

Margaret Brandwein, Nasser Said-Al-Naief, Ron Gordon, Mark Urken

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Background: Clear cell odontogenic carcinoma (CCOC), which has been described within the past 2 decades, is a rare odontogenic tumor that tends to occur in the mandible of older adults, with a predilection for women. It is potentially aggressive and capable of multiple local recurrences and locoregional and distant metastases. Objectives: To report the clinicopathologic findings and follow-up of a case of CCOC and to review the literature. Design: Case report and literature review. Main Outcome Measurements: Findings from histologic analysis, immunohistochemistry, and electron microscopy. Results: An 81-year-old woman experienced 3 locoregional recurrences within 21 months of initial therapy. She is presently disease free, 4.5 years after initial resection, having received multiple resections and adjuvant radiotherapy. Conclusions: The diagnosis of CCOC must be considered in the differential diagnosis of jaw tumors with a clear cell component. For these tumors, resection with negative margins is the treatment of choice because more conservative surgery (eg, curettage) inevitably results in recurrence and/or metastasis. Adjuvant radiotherapy is a rational option for tumors that have eroded cortex.

Original languageEnglish (US)
Pages (from-to)1089-1095
Number of pages7
JournalArchives of Otolaryngology - Head and Neck Surgery
Issue number9
StatePublished - Sep 2002
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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