@article{26dc2352bd2b4434a044a480ac99e4f5,
title = "Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study",
abstract = "Most patients with gastrointestinal stromal tumor (GIST) have activating mutations in KIT/PDGFRA and are initially responsive to tyrosine kinase inhibitors (TKI). The acquisition of secondary mutations leads to refractory/relapsed disease. This study reports the results of an analysis from the phase III INVICTUS study (NCT03353753) characterizing the genomic heterogeneity of tumors from patients with advanced GIST and evaluating ripretinib efficacy across KIT/PDGFRA mutation subgroups.",
author = "Sebastian Bauer and Heinrich, {Michael C.} and Suzanne George and Zalcberg, {John R.} and Cesar Serrano and Hans Gelderblom and Jones, {Robin L.} and Steven Attia and Gina D'Amato and Ping Chi and Peter Reichardt and Julie Meade and Ying Su and Rodrigo Ruiz-Soto and Blay, {Jean Yves} and Mehren, {Margaret Von} and Patrick Sch€offski",
note = "Publisher Copyright: {\textcopyright} 2021 American Association for Cancer Research Inc.. All rights reserved.",
year = "2021",
month = dec,
day = "1",
doi = "10.1158/1078-0432.CCR-21-1864",
language = "English (US)",
volume = "27",
pages = "6333--6342",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "23",
}