Clinical Epidemiology, Evaluation, and Management of Dementia in Parkinson Disease

Delaram Safarpour, Allison W. Willis

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


The prevalence of neurodegenerative diseases such as Parkinson disease (PD) will increase substantially, due to the aging of the population and improved treatments leading to better disease-related outcomes. Dementia is the most common nonmotor symptom in PD, and most patients with PD will have cognitive dysfunction and cognitive decline in the course of their disease. The development of cognitive dysfunction in PD greatly limits the ability to participate in activities of daily living and can be a tipping point for nursing home placement or major caregiver stress. Understanding the different causes of dementia and how to reduce the incidence and impact of secondary cognitive dysfunction in PD are necessary skills for primary care physicians and neurologists. In this review, we discuss the clinical epidemiology of dementia in PD with an emphasis on preventable cognitive dysfunction, present tools for outpatient evaluation of cognitive dysfunction, and describe current pharmacological treatments for dementia in PD.

Original languageEnglish (US)
Pages (from-to)585-594
Number of pages10
JournalAmerican Journal of Alzheimer's Disease and Other Dementias
Issue number7
StatePublished - Nov 1 2016
Externally publishedYes


  • Parkinson disease
  • Parkinson disease with dementia
  • dementia
  • epidemiology
  • mild cognitive impairment

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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