Clinical utility of magnetic resonance thermal imaging (MRTI) for realtime guidance of deep hyperthermia

P. R. Stauffer, O. I. Craciunescu, P. F. Maccarini, C. Wyatt, K. Arunachalam, O. Arabe, V. Stakhursky, B. Soher, J. R. MacFall, Z. Li, W. T. Joines, S. Rangarao, K. S. Cheng, S. K. Das, C. D. Martins, C. Charles, M. W. Dewhirst, T. Wong, E. Jones, Z. Vujaskovic

Research output: Contribution to journalConference articlepeer-review

25 Scopus citations


A critical need has emerged for volumetric thermometry to visualize 3D temperature distributions in real time during deep hyperthermia treatments used as an adjuvant to radiation or chemotherapy for cancer. For the current effort, magnetic resonance thermal imaging (MRTI) is used to measure 2D temperature rise distributions in four cross sections of large extremity soft tissue sarcomas during hyperthermia treatments. Novel hardware and software techniques aredescribed which improve the signal to noise ratio of MR images, minimize motion artifact from circulating coupling fluids, and provide accurate high resolution volumetric thermal dosimetry. For the first 10 extremity sarcoma patients, the mean difference between MRTI region of interest and adjacent interstitial point measurements during the period of steady state temperature was 0.85°C. With 1min temporal resolution of measurements in four image planes, this noninvasive MRTI approach has demonstrated its utility for accurate monitoring and realtime steering of heat into tumors at depth in the body.

Original languageEnglish (US)
Article number71810I
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
StatePublished - 2009
Externally publishedYes
EventEnergy-based Treatment of Tissue and Assessment V - San Jose, CA, United States
Duration: Jan 25 2009Jan 26 2009


  • Deep Hyperthermia
  • Magnetic Resonance Temperature Imaging
  • Non-Invasive Thermometry
  • Radiofrequency Phased Array Heating

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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