Clinicopathologic correlation of stage 2 macular hole

Thomas S. Hwang, David J. Wilson, Michael L. Klein

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


PURPOSE: To provide histopathologic correlation of the appearance of a stage 2 macular hole. METHODS: A 79-year-old woman presented with a recent onset of mildly decreased vision in the right eye. With slit-lamp biomicroscopic examination and fundus photography, she was diagnosed as having a stage 2 macular hole. Her vision remained stable thereafter without intervention for 15 months. She died 6 months after her final follow-up examination. Postmortem histopathologic examination of the right eye was carried out by light microscopy of conventional and immunoperoxidase-stained sections. RESULTS: The clinical appearance of a stage 2 macular hole in this patient corresponded with findings of intraretinal splitting, which extended beyond an area of surface retinal defect. CONCLUSION: Surface retinal defects associated with intraretinal splitting are a pathway in the development of a macular hole.

Original languageEnglish (US)
Pages (from-to)92-95
Number of pages4
Issue number1
StatePublished - Jan 2006


  • Clinicopathologic correlation
  • Macular hole
  • Stage 2 maculopathy

ASJC Scopus subject areas

  • Ophthalmology


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