Clonality and Lymphoproliferative Lesions

Michael P. Davey, Thomas A. Waldmann

Research output: Contribution to journalEditorialpeer-review

26 Scopus citations


It is much easier for the hematologist or oncologist to arrive at a diagnosis explaining lymphocytosis, lymphadenopathy, or abnormal lymphocytic infiltrations of bone marrow or skin if the cells involved can be shown to originate from a clone. Attempts to define the clonality of cells in lymphoproliferative lesions have usually followed one of three standard approaches: the determination that only a single immunoglobulin light chain, either kappa or lambda, is expressed; the demonstration of a specific cytogenetic abnormality; or the expression of only a single allele for glucose-6-phosphate dehydrogenase within the tumor of a female patient who is heterozygous for…

Original languageEnglish (US)
Pages (from-to)509-511
Number of pages3
JournalNew England Journal of Medicine
Issue number8
StatePublished - Aug 21 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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