TY - JOUR
T1 - Cloning, structure, and chromosome localization of the mouse Glutaryl-CoA dehydrogenase gene
AU - Koeller, David M.
AU - DiGiulio, Kathleen Axtell
AU - Angeloni, Stephen V.
AU - Dowler, Lisa L.
AU - Frerman, Frank E.
AU - White, Robert A.
AU - Goodman, Stephen I.
PY - 1995/8/10
Y1 - 1995/8/10
N2 - Glutaryl-CoA dehydrogenase (GCDH) is a nuclear-encoded, mitochondrial matrix enzyme. In humans, deficiency of GCDH leads to glutaric acidemia type I, an inherited disorder of amino acid metabolism characterized by a progressive neurodegenerative disease. In this report we describe the cloning and structure of the mouse GCDH (Gcdh) gene and cDNA and its chromosomal localization. The mouse Gcdh cDNA is 1.75 kb long and contains an open reading frame of 438 amino acids. The amino acid sequences of mouse, human, and pig GCDH are highly conserved. The mouse Gcdh gene contains 11 exons and spans 7 kb of genomic DNA. Gcdh was mapped by backcross analysis to mouse chromosome 8 within a region that is homologous to a region of human chromosome 19, where the human gene was previously mapped.
AB - Glutaryl-CoA dehydrogenase (GCDH) is a nuclear-encoded, mitochondrial matrix enzyme. In humans, deficiency of GCDH leads to glutaric acidemia type I, an inherited disorder of amino acid metabolism characterized by a progressive neurodegenerative disease. In this report we describe the cloning and structure of the mouse GCDH (Gcdh) gene and cDNA and its chromosomal localization. The mouse Gcdh cDNA is 1.75 kb long and contains an open reading frame of 438 amino acids. The amino acid sequences of mouse, human, and pig GCDH are highly conserved. The mouse Gcdh gene contains 11 exons and spans 7 kb of genomic DNA. Gcdh was mapped by backcross analysis to mouse chromosome 8 within a region that is homologous to a region of human chromosome 19, where the human gene was previously mapped.
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U2 - 10.1006/geno.1995.1182
DO - 10.1006/geno.1995.1182
M3 - Article
C2 - 7490088
AN - SCOPUS:0029150403
SN - 0888-7543
VL - 28
SP - 508
EP - 512
JO - Genomics
JF - Genomics
IS - 3
ER -