Voltage-activated Ca 2+ channels (VACCs) mediate Ca 2+ influx to trigger action potentialg-evoked neurotransmitter release, but the mechanism by which Ca 2+ regulates spontaneous transmission is unclear. We found that VACCs are the major physiological triggers for spontaneous release at mouse neocortical inhibitory synapses. Moreover, despite the absence of a synchronizing action potential, we found that spontaneous fusion of a GABA-containing vesicle required the activation of multiple tightly coupled VACCs of variable type.
|Original language||English (US)|
|Number of pages||3|
|State||Published - Sep 2012|
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