Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization

Marina E. Wolf; Michael Jeziorski

doi:10.1016/0006-8993(93)90913-8

Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization

Marina E. Wolf, Michael Jeziorski

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Although coadministration of N-methyl-d-aspartate (NMDA) antagonists has been reported to prevent behavioral sensitization to psychomotor stimulants, it has been suggested that this effect is transitory and that sensitization is unmasked after longer periods of drug abstinence. To test this, rats were coadministered either amphetamine, cocaine, or morphine with the NMDA antagonist MK-801 and tested for sensitization after 7-10 days of abstinence. No sensitization was observed, suggesting that NMDA antagonists do not transiently mask sensitization but instead interfere with long-term processes responsible for its development.

Original language	English (US)
Pages (from-to)	291-294
Number of pages	4
Journal	Brain research
Volume	613
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(93)90913-8
State	Published - Jun 11 1993
Externally published	Yes

Keywords

Dopamine
Drug of abuse
Locomotion
NMDA receptor

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)90913-8

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title = "Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization",

abstract = "Although coadministration of N-methyl-d-aspartate (NMDA) antagonists has been reported to prevent behavioral sensitization to psychomotor stimulants, it has been suggested that this effect is transitory and that sensitization is unmasked after longer periods of drug abstinence. To test this, rats were coadministered either amphetamine, cocaine, or morphine with the NMDA antagonist MK-801 and tested for sensitization after 7-10 days of abstinence. No sensitization was observed, suggesting that NMDA antagonists do not transiently mask sensitization but instead interfere with long-term processes responsible for its development.",

keywords = "Dopamine, Drug of abuse, Locomotion, NMDA receptor",

author = "Wolf, {Marina E.} and Michael Jeziorski",

note = "Funding Information: This work was supported by US Public Service Grant DA-07735 (M.W.), the National Alliance for Research on Schizophrenia and Depression (M.W.), the Pharmaceutical Manufacturers Association Foundation (M.W.), and a National Research Service Award (DA 05434) to M.J.",

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T1 - Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization

AU - Wolf, Marina E.

AU - Jeziorski, Michael

N1 - Funding Information: This work was supported by US Public Service Grant DA-07735 (M.W.), the National Alliance for Research on Schizophrenia and Depression (M.W.), the Pharmaceutical Manufacturers Association Foundation (M.W.), and a National Research Service Award (DA 05434) to M.J.

PY - 1993/6/11

Y1 - 1993/6/11

N2 - Although coadministration of N-methyl-d-aspartate (NMDA) antagonists has been reported to prevent behavioral sensitization to psychomotor stimulants, it has been suggested that this effect is transitory and that sensitization is unmasked after longer periods of drug abstinence. To test this, rats were coadministered either amphetamine, cocaine, or morphine with the NMDA antagonist MK-801 and tested for sensitization after 7-10 days of abstinence. No sensitization was observed, suggesting that NMDA antagonists do not transiently mask sensitization but instead interfere with long-term processes responsible for its development.

AB - Although coadministration of N-methyl-d-aspartate (NMDA) antagonists has been reported to prevent behavioral sensitization to psychomotor stimulants, it has been suggested that this effect is transitory and that sensitization is unmasked after longer periods of drug abstinence. To test this, rats were coadministered either amphetamine, cocaine, or morphine with the NMDA antagonist MK-801 and tested for sensitization after 7-10 days of abstinence. No sensitization was observed, suggesting that NMDA antagonists do not transiently mask sensitization but instead interfere with long-term processes responsible for its development.

KW - Dopamine

KW - Drug of abuse

KW - Locomotion

KW - NMDA receptor

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Coadministration of MK-801 with amphetamine, cocaine or morphine prevents rather than transiently masks the development of behavioral sensitization

Abstract

Keywords

ASJC Scopus subject areas

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