TY - JOUR
T1 - Cognitive impairment and dementia in patients with Parkinson disease
AU - Leverenz, James B.
AU - Quinn, Joseph F.
AU - Zabetian, Cyrus
AU - Zhang, Jing
AU - Montine, Kathleen S.
AU - Montine, Thomas J.
PY - 2009
Y1 - 2009
N2 - Parkinson disease (PD) is an already prevalent neurodegenerative disease that is poised to at least double over the next 25 years. Although best known for its characteristic movement disorder, PD is now appreciated commonly to cause cognitive impairment, including dementia, and behavioral changes. Dementia in patients with PD is consequential and has been associated with reduced quality of life, shortened survival, and increased caregiver distress. Here we review clinical presentation and progression, pathological bases, identification of genetic risk factors, development of small molecule biomarkers, and emerging treatments for cognitive impairment in patients with PD.
AB - Parkinson disease (PD) is an already prevalent neurodegenerative disease that is poised to at least double over the next 25 years. Although best known for its characteristic movement disorder, PD is now appreciated commonly to cause cognitive impairment, including dementia, and behavioral changes. Dementia in patients with PD is consequential and has been associated with reduced quality of life, shortened survival, and increased caregiver distress. Here we review clinical presentation and progression, pathological bases, identification of genetic risk factors, development of small molecule biomarkers, and emerging treatments for cognitive impairment in patients with PD.
KW - Alzheimer disease
KW - Cognitive impairment
KW - Demenita with Lewy bodies
KW - Dementia
KW - Parkinson disease
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U2 - 10.2174/156802609789378218
DO - 10.2174/156802609789378218
M3 - Review article
C2 - 19754405
AN - SCOPUS:74249120831
SN - 1568-0266
VL - 9
SP - 903
EP - 912
JO - Current topics in medicinal chemistry
JF - Current topics in medicinal chemistry
IS - 10
ER -