TY - JOUR
T1 - Collagenase Levels in a New Model of Experimental Herpetic Interstitial Keratitis
AU - Campbell, Robert
AU - Pavan-Langston, Deborah
AU - Lass, Jonathan
AU - Berman, Michael
AU - Gage, Janet
AU - Albert, Daniel
PY - 1980/5
Y1 - 1980/5
N2 - • A reproducible model of severe herpetic interstitial keratitis was developed by injecting live herpes simplex virus type 2 intrastromally into the corneas of presensitized rabbits. Herpes-infected corneas showed significantly more stromal infiltration and vascularization, iritis, conjunctivitis, and epithelial disease than the control corneas injected with cell supernatant without virus. Levels of total collagenase detected in the culture media of the herpes-infected corneas were high and were similar to those observed previously in alkali-burned rabbit corneas. Unlike alkali-burned corneas, the herpes-infected corneas showed much more of the enzyme in the latent form during the first two days of culture.
AB - • A reproducible model of severe herpetic interstitial keratitis was developed by injecting live herpes simplex virus type 2 intrastromally into the corneas of presensitized rabbits. Herpes-infected corneas showed significantly more stromal infiltration and vascularization, iritis, conjunctivitis, and epithelial disease than the control corneas injected with cell supernatant without virus. Levels of total collagenase detected in the culture media of the herpes-infected corneas were high and were similar to those observed previously in alkali-burned rabbit corneas. Unlike alkali-burned corneas, the herpes-infected corneas showed much more of the enzyme in the latent form during the first two days of culture.
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U2 - 10.1001/archopht.1980.01020030913022
DO - 10.1001/archopht.1980.01020030913022
M3 - Article
C2 - 6246865
AN - SCOPUS:0018893695
SN - 0003-9950
VL - 98
SP - 919
EP - 923
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 5
ER -