Combination glutathione and anthocyanins as an alternative for skin care during external-beam radiation

T. Miko Enomoto, Thomas Johnson, Noel Peterson, Louis Homer, Deb Walts, Nathalie Johnson, Johann Cunningham

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Objective: Radiation dermatitis during therapy for breast malignancy can cause significant morbidity and delay treatment. RayGel (reduced glutathione and anthocyanins; Integrative Therapies, Portland, OR) appears to decrease this skin reaction, prompting us to undertake an objective evaluation of RayGel's effectiveness. Methods: Patients undergoing whole breast external-beam irradiation were randomized to treatment with placebo or RayGel. Patients and investigators/staff were blinded to treatment assignment. Skin reaction was documented by photograph and severity scale. Results: Thirty-two patients were enrolled. Thirty patients were randomized to receive placebo (n = 15) or RayGel (n = 15). Scores were calculated by percent of breast skin involved and grade of reaction. The group receiving RayGel had a lower average score, 93.7, versus the placebo group, 123.3. Conclusion: RayGel provides skin protection during radiation therapy, superior to that observed with standard skin care and placebo. This formula may reduce discomfort associated with breast irradiation and thereby allow more consistent completion of radiation courses for the treatment of breast cancer.

Original languageEnglish (US)
Pages (from-to)627-631
Number of pages5
JournalAmerican journal of surgery
Issue number5 SPEC. ISS.
StatePublished - May 2005


  • Glutathione
  • Radiation
  • Skin care

ASJC Scopus subject areas

  • Surgery


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