TY - JOUR
T1 - Comorbidity and functional mobility in persons with Parkinson disease
AU - King, Laurie A.
AU - Priest, Kelsey C.
AU - Nutt, John
AU - Chen, Yiyi
AU - Chen, Zunqiu
AU - Melnick, Marsha
AU - Horak, Fay
N1 - Publisher Copyright:
© 2014 American Congress of Rehabilitation Medicin.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Objectives To report the frequency, severity, and types of comorbidities in people with Parkinson disease (PD) using a validated self-report comorbidity screening tool, and to determine the relationship between comorbidity and functional mobility.Design A secondary analysis and cross-sectional observational study design.Setting University hospital; outpatient balance disorders laboratory.Participantsg Persons with mild to moderate idiopathic PD (N=76). Intervention Not applicable.Main Outcome Measures The Cumulative Illness Rating Scale-Geriatric (CIRS-G) and a comprehensive mobility assessment including gait (distance walked in 3min), balance (mini-Balance Evaluation Systems Test), and physical function (Physical Performance Test).Results All participants reported comorbidities in addition to their diagnosed PD. The average ± SD number of comorbidities was 6.96±2.0 (range, 2-11), and the total CIRS-G score ± SD was 12.7±4.8. The most commonly reported organ systems with comorbidity were eyes and ears (89%), psychiatric (68%), musculoskeletal (64%), lower gastrointestinal (62%), respiratory (60.5%), upper gastrointestinal (59.2%), and genitourinary (53.9%). The total CIRS-G score was significantly related to functional mobility: gait (r=-.53, P=.0001), balance (r=-.43, P=.0003), and physical performance (r=-.36, P=.0041). Of the original 14 organ systems measured, there were 7 systems that, when combined, best predicted gait performance, 6 systems combined that best predicted balance performance, and 4 systems combined that predicted functional performance.Conclusions This study reports a high frequency of multiple medical system comorbidity in people with mild to moderate PD. Furthermore, comorbidity scores were associated with mobility disability: gait, balance, and physical function. Early intervention is important to delay mobility disability in PD, and we recommend that people with PD found to have comorbidities should be screened for balance and gait deficits.
AB - Objectives To report the frequency, severity, and types of comorbidities in people with Parkinson disease (PD) using a validated self-report comorbidity screening tool, and to determine the relationship between comorbidity and functional mobility.Design A secondary analysis and cross-sectional observational study design.Setting University hospital; outpatient balance disorders laboratory.Participantsg Persons with mild to moderate idiopathic PD (N=76). Intervention Not applicable.Main Outcome Measures The Cumulative Illness Rating Scale-Geriatric (CIRS-G) and a comprehensive mobility assessment including gait (distance walked in 3min), balance (mini-Balance Evaluation Systems Test), and physical function (Physical Performance Test).Results All participants reported comorbidities in addition to their diagnosed PD. The average ± SD number of comorbidities was 6.96±2.0 (range, 2-11), and the total CIRS-G score ± SD was 12.7±4.8. The most commonly reported organ systems with comorbidity were eyes and ears (89%), psychiatric (68%), musculoskeletal (64%), lower gastrointestinal (62%), respiratory (60.5%), upper gastrointestinal (59.2%), and genitourinary (53.9%). The total CIRS-G score was significantly related to functional mobility: gait (r=-.53, P=.0001), balance (r=-.43, P=.0003), and physical performance (r=-.36, P=.0041). Of the original 14 organ systems measured, there were 7 systems that, when combined, best predicted gait performance, 6 systems combined that best predicted balance performance, and 4 systems combined that predicted functional performance.Conclusions This study reports a high frequency of multiple medical system comorbidity in people with mild to moderate PD. Furthermore, comorbidity scores were associated with mobility disability: gait, balance, and physical function. Early intervention is important to delay mobility disability in PD, and we recommend that people with PD found to have comorbidities should be screened for balance and gait deficits.
KW - Comorbidity
KW - Parkinson disease
KW - Postural balance
KW - Rehabilitation
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U2 - 10.1016/j.apmr.2014.07.396
DO - 10.1016/j.apmr.2014.07.396
M3 - Article
C2 - 25102383
AN - SCOPUS:84908304611
SN - 0003-9993
VL - 95
SP - 2152
EP - 2157
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
IS - 11
ER -