Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha

Aaron Hardin, Kimberly A. Nevonen, Walter L. Eckalbar, Lucia Carbone, Nadav Ahituv

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Mastomys are the most widespread African rodent and carriers of various diseases such as the plague or Lassa virus. In addition, mastomys have rapidly gained a large number of mammary glands. Here, we generated a genome, variome, and transcriptomes for Mastomys coucha. As mastomys diverged at similar times from mouse and rat, we demonstrate their utility as a comparative genomic tool for these commonly used animal models. Furthermore, we identified over 500 mastomys accelerated regions, often residing near important mammary developmental genes or within their exons leading to protein sequence changes. Functional characterization of a noncoding mastomys accelerated region, located in the HoxD locus, showed enhancer activity in mouse developing mammary glands. Combined, our results provide genomic resources for mastomys and highlight their potential both as a comparative genomic tool and for the identification of mammary gland number determining factors.

Original languageEnglish (US)
Pages (from-to)2805-2812
Number of pages8
JournalMolecular Biology and Evolution
Issue number12
StatePublished - Dec 1 2019


  • Comparative genomics
  • Mastomys
  • mammary glands

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


Dive into the research topics of 'Comparative Genomic Characterization of the Multimammate Mouse Mastomys coucha'. Together they form a unique fingerprint.

Cite this