Composite glandular-endocrine cell carcinoma of the common bile duct

Genichiro Edakuni, Eizaburo Sasatomi, Toshimi Satoh, Osamu Tokunaga, Kohji Miyazaki

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


A rare case of composite glandular-endocrine cell carcinoma of the common bile duct is presented. Histologically, this tumor consisted of adenocarcinoma and small-cell neuroendocrine carcinoma, with a transition between the two components. The two distinct areas of the tumor were immunohistochemically different, whereas the transitional zone exhibited characteristics of both areas. These features suggest that the tumor arose from a multipotential stem cell. Although it has been reported that the presence of neuroendocrine differentiation in carcinomas indicates a poor prognosis, the patient in the present case was well at the time of writing this report. This may be due to the fact that adenocarcinoma, which characteristically has a low proliferative activity, constituted the majority of the tumor.

Original languageEnglish (US)
Pages (from-to)487-490
Number of pages4
JournalPathology International
Issue number6
StatePublished - 2001
Externally publishedYes


  • Adenocarcinoma
  • Common bile duct
  • Composite carcinoma
  • Endocrine cell carcinoma
  • Ki-67

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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